The long-range objectives of the UC Davis MMPC Complications and Pathology Core are to provide detailed metabolic phenotyping of mice for the complications of diabetes and obesity. We will focus our efforts on comprehensively phenotyping macrovascular and microvascular complications of diabetes and obesity. Diabetic and obesity phenotyping complications will be accomplished through the coordinated distribution and focused analyses of mice by the leader and co-leader of the core, Drs. Rutledge and Griffey, respectively. In addition, investigators using the core will gain access to the academic portal at UC Davis for comprehensive analysis of macrovascular and microvascular complications of diabetes and obesity. Investigators participating in this core and who have essential and special capabilities to phenotype macrovascular and microvascular complications are Drs. Rutledge, Griffey, Villablanca, Huser, Jin, Chiamvimovat, Ferrara, Nolta, and Van de Water.We have developed a comprehensive list of standard cardiovascular phenotyping assays. Review ofthe current list of national MMPC assays reveals needs in some areas. The UC Davis Complications and Pathology Core will fill some of these unmet needs using novel or new state-of-the-art approaches. These standard and new state-of-the-art and novel assays will be integrated with the other cores to better understand adipocyte biology, fatty liver disease, and insulin resistance.UC Davis has existing capabilities in mouse cardiovascular anatomy, physiology, pathology, and micro imaging that are outstanding. We will capitalize upon these assets to provide sophisticated cardiovascular phenotyping to users of the MMPC. Our mission is to ensure that efficient and accurate standard and novel and new state-of-the-art assays of submitted mice are provided to users ofthe UC Davis MMPC.

Public Health Relevance

Mouse models of diabetes, diabetic complications, obesity and other related disorders have been invaluable for elucidating the disease potential, pathogenesis and treatment of these conditions in the human population. The Complications and Pathology Core will conduct procedures and analyses on mouse lines submitted to the MMPC-UCD in order to identify potentail mouse models of human disease for study.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
United States
Zip Code
Huang, Wei-Hsiang; Guenthner, Casey J; Xu, Jin et al. (2016) Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. Neuron 92:392-406
Dickel, Diane E; Barozzi, Iros; Zhu, Yiwen et al. (2016) Genome-wide compendium and functional assessment of in vivo heart enhancers. Nat Commun 7:12923
Ng, Kit Fai; Anderson, Steve; Mayo, Patrice et al. (2016) Characterizing blood-brain barrier perturbations after exposure to human triglyceride-rich lipoprotein lipolysis products using MRI in a rat model. Magn Reson Med 76:1246-51
Lloyd, K C Kent; Khanna, Chand; Hendricks, William et al. (2016) Precision medicine: an opportunity for a paradigm shift in veterinary medicine. J Am Vet Med Assoc 248:45-8
Aung, Hnin Hnin; Altman, Robin; Nyunt, Tun et al. (2016) Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways. J Lipid Res 57:955-68
Green, Adrian J; Graham, James L; Gonzalez, Eduardo A et al. (2016) Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats. Reprod Toxicol :
Lloyd, Kent; Franklin, Craig; Lutz, Cat et al. (2015) Reproducibility: use mouse biobanks or lose them. Nature 522:151-3
Flynn, Charles Robb; Albaugh, Vance L; Cai, Steven et al. (2015) Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery. Nat Commun 6:7715
Walton, Jeffrey H; Ng, Kit Fai; Anderson, Steven E et al. (2015) MRI measurement of blood-brain barrier transport with a rapid acquisition refocused echo (RARE) method. Biochem Biophys Res Commun 463:479-82
Bettaieb, Ahmed; Hosein, Ellen; Chahed, Samah et al. (2015) Decreased adiposity and enhanced glucose tolerance in shikonin treated mice. Obesity (Silver Spring) 23:2269-77

Showing the most recent 10 out of 55 publications