The Administrative Core of the Michigan Regional Comprehensive Metabolomic Resource Cores (MRC2) will coordinate, integrate and promote appropriate use of metabolomic services within the Resource Core and will support new learning to ensure cost-effective use of metabolomics to advance the research efforts of the scientific community. To accomplish these goals, the Administrative Core will provide administrative infrastructure to coordinate research in the MRC2 Cores and promote the integration of metabolomic technologies into preclinical, clinical and translational research studies. The Core will act as the interface for internal and external users of the MRC2 technology to ensure appropriate utilization of resources. It will also coordinate with other Regional Comprehensive Metabolomics Resource Cores (RCMRCs) and with the Data Repository and Coordinating Center (DRCC) to advance cost-effective metabolomics research. To disseminate information regarding metabolomics services and research the Administrative Core will support a user-friendly, National Institutes of Health (NIH)-Common Fund-linked Website which will also serve as the interface for MRC2 customer use to interact with the various Cores. The Core will also ensure appropriate expenditures of funds and adjust MRC^ budgetary allotment as appropriate to complete the mission of the MRC2. Finally, the Core will establish appropriate recharge rates for the services provided by the MRC2 and work with the Biomedical Research Core Facilities, Financial Operations of the Medical School and the UM Business School to ensure the smooth transition of the MRC2 to a self-sustaining research and education entity.

Public Health Relevance

Appropriate management of resources of the metabolomics enterprise requires close monitoring and appropriate financial and human resource allocation. The Administrative Core will provide this oversight and also provide support for dissemination of information via a website to the research community and the public. The Administrative Core will also work with the appropriate national and University of Michigan administrative structures to ensure the continued financial success of the MRC2.

National Institute of Health (NIH)
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Noori, S; McNamara, P; Jain, A et al. (2015) Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation. J Perinatol 35:123-7
Puskarich, Michael A; Finkel, Michael A; Karnovsky, Alla et al. (2015) Pharmacometabolomics of l-carnitine treatment response phenotypes in patients with septic shock. Ann Am Thorac Soc 12:46-56
Lanning, Nathan J; Looyenga, Brendan D; Kauffman, Audra L et al. (2014) A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels. Cell Rep 7:907-17
Clyman, Ronald I; Wickremasinghe, Andrea; Merritt, T Allen et al. (2014) Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones. J Pediatr 164:1449-55.e1
Bassis, Christine M; Theriot, Casey M; Young, Vincent B (2014) Alteration of the murine gastrointestinal microbiota by tigecycline leads to increased susceptibility to Clostridium difficile infection. Antimicrob Agents Chemother 58:2767-74
Theriot, Casey M; Koenigsknecht, Mark J; Carlson Jr, Paul E et al. (2014) Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection. Nat Commun 5:3114
Parlee, Sebastian D; Simon, Becky R; Scheller, Erica L et al. (2014) Administration of saccharin to neonatal mice influences body composition of adult males and reduces body weight of females. Endocrinology 155:1313-26
Michaud, Dominique S; Izard, Jacques (2014) Microbiota, oral microbiome, and pancreatic cancer. Cancer J 20:203-6
Wardlaw, Sharon L; Burant, Charles F; Klein, Samuel et al. (2014) Continuous 24-hour leptin, proopiomelanocortin, and amino acid measurements in human cerebrospinal fluid: correlations with plasma leptin, soluble leptin receptor, and amino acid levels. J Clin Endocrinol Metab 99:2540-8
Evans, Charles R; Karnovsky, Alla; Kovach, Melissa A et al. (2014) Untargeted LC-MS metabolomics of bronchoalveolar lavage fluid differentiates acute respiratory distress syndrome from health. J Proteome Res 13:640-9

Showing the most recent 10 out of 30 publications