The overall intent of the Outreach and Promotion Core is to provide integrated scientific, educational, administrative, and financial support for outreach efforts, training, and pilot projects related to the West Coast Central Comprehensive Metabolomics Resource Core (WC^MRC) mission. The Core will incorporates highly successful aspects of the UC Davis Clinical and Translational Science Center (CTSC) programs including the Research Education, Training, and Career Development Program, the Pilot Translational and Clinical Studies Program, and the Translational Technologies, Methodologies, and Resources Program that have been developed and thoroughly tested during 6 years of NIH funding. Offerings through the CTSC Education Program will be supplemented with new translational metabolomics core courses, seminars, and workshops that will provide crucial exposure of a spectrum of trainees to the metabolomics field. Examples for such workshops offered through this core will be Glycobiology and the Microbiome, Cancer Metabolism, Lipid Metabolism in Cardiovascular Diseases and Metabolic Pathways in Animal Models. Examples for specific metabolomic training courses are Metabolomics Basics, Advanced Metabolomics and Genomics in Metabolic Diseases, to be inclusive for all trainees in the WC^MRC with hands-on training experience opportunities. Importantly, the Core will engage regional and local scientists to participate in pilot and feasibility project programs. These programs aim to spark innovative and collaborative scientific endeavors by supporting and facilitating robust new research paradigms, technologies, and tools, and through partnerships that enhance team science. The basic principles in executing the pilot program include: (1) a requirement for submissions to represent new multidisciplinary teams;(2) the inclusion of trainees and exposure of these trainees to the WC^MRC and CTSC educational offerings;(3) active solicitation of partnerships and leveraging of funds from other UC Davis pilot programs;and (4) linking program announcements to translational workshops.

Public Health Relevance

Studying and understanding metabolism in a comprehensive way is important to fight metabolic diseases, including diabetes, heart attacks, strokes, and cancer. Educating the next generation of scientist who can use modern tools in metabolic analysis lays the foundation for breakthroughs in understanding and treating metabolic diseases.

National Institute of Health (NIH)
Resource-Related Research Projects--Cooperative Agreements (U24)
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Guerrero, Andres; Lerno, Larry; Barile, Daniela et al. (2015) Top-down analysis of highly post-translationally modified peptides by Fourier transform ion cyclotron resonance mass spectrometry. J Am Soc Mass Spectrom 26:453-9
Ma, Yan; Kind, Tobias; Yang, Dawei et al. (2014) MS2Analyzer: A software for small molecule substructure annotations from accurate tandem mass spectra. Anal Chem 86:10724-31
Noto, Antonio; Fanos, Vassilios; Barberini, Luigi et al. (2014) The urinary metabolomics profile of an Italian autistic children population and their unaffected siblings. J Matern Fetal Neonatal Med 27 Suppl 2:46-52
Schuchardt, Jan Philipp; Schneider, Inga; Willenberg, Ina et al. (2014) Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA. Prostaglandins Other Lipid Mediat 109-111:23-31
Schuster, Gertrud U; Bratt, Jennifer M; Jiang, Xiaowen et al. (2014) Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice. Am J Respir Cell Mol Biol 50:626-36
Snowden, Stuart G; Grapov, Dmitry; Settergren, Magnus et al. (2014) High-dose simvastatin exhibits enhanced lipid-lowering effects relative to simvastatin/ezetimibe combination therapy. Circ Cardiovasc Genet 7:955-64
Ulu, Arzu; Stephen Lee, Kin Sing; Miyabe, Christina et al. (2014) An omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II-dependent hypertension. J Cardiovasc Pharmacol 64:87-99
Ono, Emiko; Dutile, Stefanie; Kazani, Shamsah et al. (2014) Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. Am J Respir Crit Care Med 190:886-97
Campbell, Caitlin; Grapov, Dmitry; Fiehn, Oliver et al. (2014) Improved metabolic health alters host metabolism in parallel with changes in systemic xeno-metabolites of gut origin. PLoS One 9:e84260
Cajka, Tomas; Fiehn, Oliver (2014) Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry. Trends Analyt Chem 61:192-206

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