The goal of this supplement request is to continue support for NURSA biocuration and analysis took development as they relate to NIDDK's mission. NURSA biocurators will carry out detailed, systematic curation of datasets using consistent structured vocabularies and constrained unique identifiers to provide for more accurate data retrieval. NURSA-curated datasets will be citable in full concordance with the FAIR principles. Datasets will be exposed for discovery through two major dataset search engines, NIH bioCADDIE DataMed and Thomson Reuters Web Of Science. Fourthly, journal staff in two major publishers in the field of mammalian cellular signal transduction and metabolic disease, Elsevier and Public Library of Science, will facilitate interactions between NURSA staff and authors of accepted articles to gain access to datasets. The web development team will integrate transcriptomics, ChIP-Seq, protein-protein interactions, and protein translational modifications in a single searchable resource. To ensure that we deliver to the community the curated content of most immediate use and impact, we will prioritize our curational efforts in descending order of dataset date of publication (newer > older), dataset throughput (discovery-scale vs focused hypothesis-drven) and signaling pathway level of interest (greater > lesser).

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Resource-Related Research Projects--Cooperative Agreements (U24)
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Hyde, James F
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Baylor College of Medicine
Anatomy/Cell Biology
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United States
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Davison, James M; Lickwar, Colin R; Song, Lingyun et al. (2017) Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alpha. Genome Res 27:1195-1206
Preidis, Geoffrey A; Kim, Kang Ho; Moore, David D (2017) Nutrient-sensing nuclear receptors PPAR? and FXR control liver energy balance. J Clin Invest 127:1193-1201
Tsiarli, M A; Rudine, A; Kendall, N et al. (2017) Antenatal dexamethasone exposure differentially affects distinct cortical neural progenitor cells and triggers long-term changes in murine cerebral architecture and behavior. Transl Psychiatry 7:e1153
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Xu, Yong; O'Malley, Bert W; Elmquist, Joel K (2017) Brain nuclear receptors and body weight regulation. J Clin Invest 127:1172-1180
Zhu, Bokai; Zhang, Qiang; Pan, Yinghong et al. (2017) A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms. Cell Metab 25:1305-1319.e9
McKenna, Neil J (2016) Research Resources for Nuclear Receptor Signaling Pathways. Mol Pharmacol 90:153-9
Carson, Ross; Monaghan-Nichols, A Paula; DeFranco, Donald B et al. (2016) Effects of antenatal glucocorticoids on the developing brain. Steroids 114:25-32
Frahm, Krystle A; Peffer, Melanie E; Zhang, Janie Y et al. (2016) Research Resource: The Dexamethasone Transcriptome in Hypothalamic Embryonic Neural Stem Cells. Mol Endocrinol 30:144-54
Ribas, Vicent; Drew, Brian G; Zhou, Zhenqi et al. (2016) Skeletal muscle action of estrogen receptor ? is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med 8:334ra54

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