The goal of this supplement request is to continue support for NURSA biocuration and analysis took development as they relate to NIDDK's mission. NURSA biocurators will carry out detailed, systematic curation of datasets using consistent structured vocabularies and constrained unique identifiers to provide for more accurate data retrieval. NURSA-curated datasets will be citable in full concordance with the FAIR principles. Datasets will be exposed for discovery through two major dataset search engines, NIH bioCADDIE DataMed and Thomson Reuters Web Of Science. Fourthly, journal staff in two major publishers in the field of mammalian cellular signal transduction and metabolic disease, Elsevier and Public Library of Science, will facilitate interactions between NURSA staff and authors of accepted articles to gain access to datasets. The web development team will integrate transcriptomics, ChIP-Seq, protein-protein interactions, and protein translational modifications in a single searchable resource. To ensure that we deliver to the community the curated content of most immediate use and impact, we will prioritize our curational efforts in descending order of dataset date of publication (newer > older), dataset throughput (discovery-scale vs focused hypothesis-drven) and signaling pathway level of interest (greater > lesser).

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
3U24DK097748-05S1
Application #
9537035
Study Section
Program Officer
Hyde, James F
Project Start
2012-09-17
Project End
2018-08-31
Budget Start
2016-09-01
Budget End
2018-08-31
Support Year
5
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
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Preidis, Geoffrey A; Kim, Kang Ho; Moore, David D (2017) Nutrient-sensing nuclear receptors PPAR? and FXR control liver energy balance. J Clin Invest 127:1193-1201
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Ribas, Vicent; Drew, Brian G; Zhou, Zhenqi et al. (2016) Skeletal muscle action of estrogen receptor ? is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med 8:334ra54

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