The goal of the NIMH Human Genetics Initiative (HGI) is to further understand the genetic and environmental etiologies of mental disorders. One of the major mechanisms for accomplishing this goal is the NIMH Center for Collaborative Genomics Research on Mental Disorders (the "Center"), which receives raw biosamples such as blood from NIMH PIs. The Center processes samples to DNA, RNA, cDNA or cell lines, which can then be submitted for genomic analyses. Along with biosamples the Center receives clinical/phenotypic data for each subject and, eventually, the results of genomic analyses. After a proprietary period, the clinical data, genomic data, DNA, RNA, cDNA and cell lines are made available to all NIMH-approved researchers through a. secure web site. This sharing of uniformly processed biological samples and clinical and genomic data from many cohorts leverages the NIMH investment in a large number of HGI grants. It provides critical research power by providing a large body of data applicable to investigations on the genetic bases for individual mental disorders. Since October 1998, >147,000 subject samples have been submitted and the Center has distributed >310,000 DNA samples and >9,000 cell lines. There have been >450 distributions of clinical and genotype data to ~340 investigators and >260 publications using these samples and data. Starting in 2011 the Center provided cell line banking and characterization services for induced pluripotent stem cells (iPSC) and their progenitor somatic cells. The Center also develops novel bioinformatics and computational genomics tools and methodologies designed to integrate and analyze large, independent sets of genotypic and phenotypic data while resolving phenotype and/or genotype discrepancies in datasets. As its guiding aim, the Center will continue to innovate in order to serve the scientific needs of NIMH PIs in a flexible and highly accessible manner, while respecting subject confidentiality, informed consent issues and PI prerogatives.

Public Health Relevance

The Center provides research the resources that will enable researchers to pinpoint the genetic causes of mental disorders. Understanding the genetics of mental disorders will likely result in new diagnostic and therapeutic approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24MH068457-12
Application #
8675287
Study Section
Special Emphasis Panel (ZMH1-ERB-C (03))
Program Officer
Lehner, Thomas
Project Start
2003-07-01
Project End
2018-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
12
Fiscal Year
2014
Total Cost
$8,990,611
Indirect Cost
$2,597,867
Name
Rutgers University
Department
Genetics
Type
Schools of Arts and Sciences
DUNS #
001912864
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Vinciotti, Veronica; Wit, Ernst C; Jansen, Rick et al. (2016) Consistency of biological networks inferred from microarray and sequencing data. BMC Bioinformatics 17:254
Treur, Jorien L; Taylor, Amy E; Ware, Jennifer J et al. (2016) Smoking and caffeine consumption: a genetic analysis of their association. Addict Biol :
den Braber, A; Zilhão, N R; Fedko, I O et al. (2016) Obsessive-compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs. Transl Psychiatry 6:e731
Sakurai, Kunie; Kurtz, Andreas; Stacey, Glyn et al. (2016) First Proposal of Minimum Information About a Cellular Assay for Regenerative Medicine. Stem Cells Transl Med 5:1345-1361
Jansen, R; Penninx, B W J H; Madar, V et al. (2016) Gene expression in major depressive disorder. Mol Psychiatry 21:339-47
de Vries, Paul S; Chasman, Daniel I; Sabater-Lleal, Maria et al. (2016) A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Hum Mol Genet 25:358-70
Oni, Eileen N; Halikere, Apoorva; Li, Guohui et al. (2016) Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele. Sci Rep 6:34341
Alexander, John; Potamianou, Hera; Xing, Jinchuan et al. (2016) Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology. Front Neurosci 10:428
Pitsiladis, Yannis P; Tanaka, Masashi; Eynon, Nir et al. (2016) Athlome Project Consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance. Physiol Genomics 48:183-90
Yu, Dongmei; Mathews, Carol A; Scharf, Jeremiah M et al. (2015) Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. Am J Psychiatry 172:82-93

Showing the most recent 10 out of 76 publications