The National Mesothelioma Virtual Bank (NMVB) consents patients to provide biospecimens (blood products and tissue) together with demographic data, occupational history and clinical data (stage, treatment and survival information) to the mesothelioma research community. The University of Pittsburgh (Pitt) is the coordinating site, and the NMVB protocol is in place at three partnering sites, New York University, Roswell Park Cancer Institute and University of Pennsylvania.
Our specific aims are to: 1) Continue to serve the mesothelioma cancer research community by collecting and distributing tissue, blood and the aforementioned data as well as increasing the NMVB cohort to 2400 patients. We will continue to document and continually evaluate the usefulness of the NMVB to the scientific community and measure its impact in collaboration with the Mesothelioma Applied Research Foundation; 2) Expand the NMVB to the University of Maryland as a site and add fresh frozen tissue and blood product collection at Roswell Park Cancer Institute. We will also add 350 cases donated by Merck Research Labs; and 3) Automate annotation of biospecimens through extraction of clinical, outcomes, and pathology data from electronic health records and cancer registry systems. We will deploy and implement a scalable informatics solution to maximize the effectiveness of the data extraction process across collaborating sites which will allow linkage to other national tissue and data sharing networks.

Public Health Relevance

The National Mesothelioma Virtual Bank (NMVB) collects and distributes tumor tissue and blood samples to the research community from consented patients. The specimens are stored with de-identified clinical data and that is made available for research. Investigators can search the study database to identify and request these materials via the NMVB website. NMVB is the largest and most accessible resource for biospecimens donated by mesothelioma patients.

Agency
National Institute of Health (NIH)
Institute
National Institute for Occupational Safety and Health (NIOSH)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
2U24OH009077-10
Application #
9244884
Study Section
Special Emphasis Panel (ZOH1-EHG (50))
Program Officer
Karr, Joan
Project Start
2016-09-01
Project End
2021-08-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
10
Fiscal Year
2016
Total Cost
$1,078,661
Indirect Cost
Name
University of Pittsburgh
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
De Rienzo, Assunta; Cook, Robert W; Wilkinson, Jeff et al. (2017) Validation of a Gene Expression Test for Mesothelioma Prognosis in Formalin-Fixed Paraffin-Embedded Tissues. J Mol Diagn 19:65-71
Nasu, Masaki; Emi, Mitsuru; Pastorino, Sandra et al. (2015) High Incidence of Somatic BAP1 alterations in sporadic malignant mesothelioma. J Thorac Oncol 10:565-76
Strange, Charlie; Senior, Robert M; Sciurba, Frank et al. (2015) Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis Study. Alpha-1 Protocol. Ann Am Thorac Soc 12:1551-60
Moller, David R; Koth, Laura L; Maier, Lisa A et al. (2015) Rationale and Design of the Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS) Study. Sarcoidosis Protocol. Ann Am Thorac Soc 12:1561-71
Amin, Waqas; Srinivasan, Malini; Song, Sang Yong et al. (2014) Use of automated image analysis in evaluation of Mesothelioma Tissue Microarray (TMA) from National Mesothelioma Virtual Bank. Pathol Res Pract 210:79-82