Tuberculosis (TB) is still a major public health challenge in Brazil. Though Brazil has moved down the list of WHO'S 22 high burden countries, it still remains 18th. This burden makes Brazil particularly suitable for TB/HIV research as one of the few low- and middle-income countries with free and universal access to both anti-TB and HAART drugs provided by the public health system. The ICOHRTA AIDS/TB in Brazil succeeded in training a cadre of investigators working in the public health system and academic institutions. This renewal application in response to PAR-08-155 intends to continue this mission of training highly motivated investigators with capacity to sustain research with impact in TB and AIDS control. This Phase II ICOHRTA AIDS/TB grant is integrated with other awards received by the Academic Program of TB, Federal University of Rio de Janeiro (FURJ) and the Center for TB Research, Johns Hopkins University including ICIDR (NIAID), CREATE (Melinda and Bill Gates Foundation), TREAT-TB (USAID), as well as other important Brazilian awards, such as the National Institute of Science and Technology in TB, awarded by the CNPq. Since September 2005, 1,332 Brazilian trainees have participated in ICOHRTA activities;45 have received or will receive M.Sc. or PhD degrees, or post-doctoral training by Brazilian Universities;and over 80 publications have appeared in peer-reviewed journals. Former trainees are now faculty members in this renewal application and others work in leadership positions in the public health system. ICOHRTA faculty members are also involved in the fight to control TB in Brazil, working closely with the Brazilian TB Control Program, the Brazilian Society of Thoracic Diseases and TB, the TB Research Network (REDE-TB), and with organizations of the civil societies at the Stop TB Partnership and the Country Coordination Mechanism of the Global Fund. This renewal proposal intends to expand training activities to other high burden areas, such as Fortaleza and Salvador in the North-East region, and Porto Alegre in the South region. Other centers in the original areas of Rio de Janeiro, Sao Paulo, and Vitoria will also participate. The main goal of the renewal application is to continue its contribution to TB control in Brazil

Public Health Relevance

The original Phase II ICOHRTA AIDS/TB in Brazil has trained 1,332 trainees since 2005, and these trainees have used this training to conduct important TB/HIV research and to become leaders in the fight to control TB in Brazil. This renewal application intends to continue the mission of training highly motivated investigators with capacity to sustain research with impact in TB and AIDS control and ultimately contribute to the control of both diseases in Brazil.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Cooperative Agreements (U2R)
Project #
3U2RTW006883-10S1
Application #
8921585
Study Section
Special Emphasis Panel (ZRG1-ICP2-B (52))
Program Officer
Mcdermott, Jeanne
Project Start
2004-04-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
10
Fiscal Year
2014
Total Cost
$50,000
Indirect Cost
$3,700
Name
Federal University of Rio de Janeiro
Department
Type
DUNS #
900848466
City
Rio de Janeiro
State
Country
Brazil
Zip Code
21941-901
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do Prado, Thiago Nascimento; Miranda, Angélica Espinosa; de Souza, Fernanda Mattos et al. (2014) Factors associated with tuberculosis by HIV status in the Brazilian national surveillance system: a cross sectional study. BMC Infect Dis 14:415
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Steffen, Ricardo Ewbank; Caetano, Rosângela; Pinto, Márcia et al. (2013) Cost-effectiveness of Quantiferon®-TB Gold-in-Tube versus tuberculin skin testing for contact screening and treatment of latent tuberculosis infection in Brazil. PLoS One 8:e59546
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Soares, E C C; Vollmer, W M; Cavalcante, S C et al. (2013) Tuberculosis control in a socially vulnerable area: a community intervention beyond DOT in a Brazilian favela. Int J Tuberc Lung Dis 17:1581-6
Takenami, Iukary; Loureiro, Camila; Machado Jr, Almerio et al. (2013) Blood Cells and Interferon-Gamma Levels Correlation in Latent Tuberculosis Infection. ISRN Pulmonol 2013:
Martins, Maria Conceicao; Giampaglia, Carmen M Saraiva; Oliveira, Rosangela S et al. (2013) Population structure and circulating genotypes of drug-sensitive and drug-resistant Mycobacterium tuberculosis clinical isolates in Sao Paulo state, Brazil. Infect Genet Evol 14:39-45
Dowdy, D W; Israel, G; Vellozo, V et al. (2013) Quality of life among people treated for tuberculosis and human immunodeficiency virus in Rio de Janeiro, Brazil. Int J Tuberc Lung Dis 17:345-7
Reis-Santos, Barbara; Locatelli, Rodrigo; Horta, Bernardo L et al. (2013) Socio-demographic and clinical differences in subjects with tuberculosis with and without diabetes mellitus in Brazil--a multivariate analysis. PLoS One 8:e62604

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