The Career Development and Training Program, directed by Developmental Director Water Stamm MD of the Administrative Core will be used by the NWRCE to increase the number and quality of basic and clinical researchers working in biodefense and emerging infectious in Region X (WA, OR, AK, ID). Promising scientists at the postdoctoral, junior faculty or senior faculty levels throughout Region X who are committed to pursuing a career in biodefense research will be 1) recruited and 2) supported by a one to three year career development award. The purpose of this funding mechanism is to make individuals competitive for other types of research funding for work on pathogens of national interest. Funds will provide for two types of programs within the Career Development plan;the Individual Career Development awards to scientists which the NWRCE has been administering during the initial award period, and Group Career Development and Training. The latter will conduct a continuing medical education (CME) course to educate primary care providers in Region X regarding the recognition and management of biodefense-related infections -- both from the individual case management and public health perspective. Our overall goal will be to develop and enhance an active and knowledgeable professional cadre to respond to infectious disease emergencies. The CME course will be undertaken in collaboration with Emergency Response Director Jeffery Duchin MD and the Puget Sound Seattle King County Health Department as a joint effort of both the Emergency Response Plan and the Group Career Development Plan.

Public Health Relevance

The Career Development and Training Program of the NWRCE is intended to 1) increase the number and quality of basic and clinical researchers working in biodefense and emerging infectious disease in Region X (WA, OR, AK, ID), and 2) enhance public health responsiveness in the event of an infectious disease emergency.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZAI1-DDS-M)
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University of Washington
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West, T Eoin; Myers, Nicolle D; Chantratita, Narisara et al. (2014) NLRC4 and TLR5 each contribute to host defense in respiratory melioidosis. PLoS Negl Trop Dis 8:e3178
Hagar, Jon A; Miao, Edward A (2014) Detection of cytosolic bacteria by inflammatory caspases. Curr Opin Microbiol 17:61-6
Majerczyk, Charlotte D; Brittnacher, Mitchell J; Jacobs, Michael A et al. (2014) Cross-species comparison of the Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia mallei quorum-sensing regulons. J Bacteriol 196:3862-71
Loomis, Wendy P; Johnson, Matthew L; Brasfield, Alicia et al. (2014) Temporal and anatomical host resistance to chronic Salmonella infection is quantitatively dictated by Nramp1 and influenced by host genetic background. PLoS One 9:e111763
Martínez, Luary C; Vadyvaloo, Viveka (2014) Mechanisms of post-transcriptional gene regulation in bacterial biofilms. Front Cell Infect Microbiol 4:38
Myers, Nicolle D; Chantratita, Narisara; Berrington, William R et al. (2014) The role of NOD2 in murine and human melioidosis. J Immunol 192:300-7
Correia, Bruno E; Bates, John T; Loomis, Rebecca J et al. (2014) Proof of principle for epitope-focused vaccine design. Nature 507:201-6
Majerczyk, Charlotte; Brittnacher, Mitchell; Jacobs, Michael et al. (2014) Global analysis of the Burkholderia thailandensis quorum sensing-controlled regulon. J Bacteriol 196:1412-24
Pruneda, Jonathan N; Smith, F Donelson; Daurie, Angela et al. (2014) E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis. EMBO J 33:437-49
Sureka, Kamakshi; Choi, Philip H; Precit, Mimi et al. (2014) The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function. Cell 158:1389-401

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