B.3.c. Career Development Projects (CDP). Two programs of the Midwestem RCE willfurther the training of scientists in biodefense and emerging infectious diseases. Research topicspursued by trainees must be focused on anthrax, botulism, hemorrhagic fever, plague, smallpox ortularemia with the intent of (i) developing therapeutics, (ii) vaccines, (iii) diagnostic devices or (iv)advancing basic knowledge of the mechanisms of disease. The first program is comprised of threefaculty awards intended to focus the career of junior or established faculty on biodefense research.As outlined by NIAID, at least one of three CDPs must be focused on basic science, and at least oneon translational/clinical science. The scope and expectations of CDP projects resembles that of N/HFirst Awards, or Doris Duke Foundation and Howard Hughes Awards, which are dissimilar to currentT, K and F NIH awards in that they encourage interested scientists with potential but limited previousNIH-funded awards/grants. Funding for CDPs is limited to $110,000 direct costs per year with a totallimit of three years of funding. CDPs are additionally supported by Core Projects (CPI-10, see below)adding shared value to RP, DP and CDP investigators in the Midwestem RCE. Trainees are guidedby established investigators of the Midwestem RCE and inter-institutional and/or inter-disciplinarymentorships are strongly encouraged. Listed below are three CDPs that have been selected forproposal submission during EB review of proposals submitted in response to the Midwestem RCERFA. CDP funding will be initiated for a period of one year and is subject to annual competitive reviewand renewal. During the review of CDPs, the outcome measures of science and training forMidwestem RCE scientists will be applied (see B.4. for detail). The review criteria for MidwestemRCE proposals are described in section A.2.c. CDPI' Professor Teresa Zembower (NU) will conductphase 1/11open-label study analyzing the clinical and immunologic effects of smallpox vaccination andthe local shedding of vaccinia virus in healthy volunteers who receive Dryvax with or withouttenofovir. Dr. Zembower will be guided by Professor Gregory Poland (MC). CDP2: Dr. Liaohai Chert,on the faculty of the Biosciences Division at ANL, will develop an early detection system forhemorrhagic fever viruses by affinity imprinting of single viral particles. Dr. Chert will be mentored byProfessor Richard Kuhn (PU). CDP3: Professor Joanna Shisler (UIUC) will examine the regulatorymechanisms of poxviridae on NF-KB mediated regulation of the host immune response. ProfessorShisler will be guided by Professor Paula Traktman (MCW). CDP4: The second program iscomprised of five Research Associate Training Awards (RATA) to be awarded each year. Funding isfor NIH level salary and laboratory support of post-doctoral trainees - no more than $40,000 directcosts for a total of one year. RATAs are awarded in conjuction with EB proposal review of trainee,trainee scientific proposal and research mentor and are described in detail in D.
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