NERCE Core A: Microbiology and Animal Resources Core Laboratory, Andrew Onderdonk, Ph.D., Harvard Medical School. The overall goal of the Core A laboratories is to provide the infrastructure, administrative support, scientific equipment and personnel for a BSL-2/ABSL-2 laboratory and animal facility for training and research with category A, B and C agents. This facility includes access to exempt and select agent strains, laboratory space for visiting investigators, and bio-safety and laboratory equipment for training prior to experimental work in the Core A BSL-3/ABSL-3 Select Agent laboratory and animal facility.
Specific aims for the Core are to train NERCE scientists and technical personnel in the proper use of BSL-3/ABSL-3 facilities and to provide trained scientific staff to support investigators with research using Category A, B and C priority pathogens. An essential specific aim for the Core A laboratory is to prepare and fully characterize master and seed lot stocks of select agents and exempt strains for all NERCE investigators and to increase collaborative research activities with NERCE sponsored scientists and across NERCE core laboratories. As part of our overall mission, the Core A laboratory participates in translational research with Category A, B, and C organisms directed at development of products and clinical interventions for emerging infectious disease threats. Within the greater community, Core A also provides support through the LRN program to the Massachusetts State Laboratory Institute and others, as requested by the SLI, involved as first responders for possible BT events. The Core A laboratory promotes the use of facilities through an outreach program to other institutions and scientists throughout the New England region.
The Core A Laboratory provides both a training laboratory and program support for investigators funded through the NERCE. Core A has focused on being able to train individual scientists interested in working with category A, B and C agents, or alternatively, to provide the necessary technical support for short term projects using a dedicated fulltime staff. This approach has provided the flexibility necessary to accommodate the many different types of projects conducted by New England investigators
|Nair, Dhanalakshmi R; Chen, Ji; Monteiro, João M et al. (2017) A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism. J Antibiot (Tokyo) 70:1009-1019|
|Huang, Nai-Jia; Pishesha, Novalia; Mukherjee, Jean et al. (2017) Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin. Nat Commun 8:423|
|Mertins, Philipp; Przybylski, Dariusz; Yosef, Nir et al. (2017) An Integrative Framework Reveals Signaling-to-Transcription Events in Toll-like Receptor Signaling. Cell Rep 19:2853-2866|
|de Wispelaere, Mélissanne; Carocci, Margot; Liang, Yanke et al. (2017) Discovery of host-targeted covalent inhibitors of dengue virus. Antiviral Res 139:171-179|
|Choo, Min-Kyung; Sano, Yasuyo; Kim, Changhoon et al. (2017) TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects. J Exp Med 214:1297-1311|
|Zheng, Huiqing; Colvin, Christopher J; Johnson, Benjamin K et al. (2017) Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Nat Chem Biol 13:218-225|
|Coulson, Garry B; Johnson, Benjamin K; Zheng, Huiqing et al. (2017) Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics. Cell Chem Biol 24:993-1004.e4|
|Vrentas, Catherine E; Moayeri, Mahtab; Keefer, Andrea B et al. (2016) A Diverse Set of Single-domain Antibodies (VHHs) against the Anthrax Toxin Lethal and Edema Factors Provides a Basis for Construction of a Bispecific Agent That Protects against Anthrax Infection. J Biol Chem 291:21596-21606|
|Helenius, Iiro Taneli; Nair, Aisha; Bittar, Humberto E Trejo et al. (2016) Focused Screening Identifies Evoxine as a Small Molecule That Counteracts CO2-Induced Immune Suppression. J Biomol Screen 21:363-71|
|Fink, Avner; Hassan, Musa A; Okan, Nihal A et al. (2016) Early Interactions of Murine Macrophages with Francisella tularensis Map to Mouse Chromosome 19. MBio 7:e02243|
Showing the most recent 10 out of 412 publications