A major objective of the Career Development and Training component of this RCE is to provide a mechanism for attracting new junior investigators to research on Bioterrorism Agents and Emerging Infectious Diseases (BA/EID) and to provide them with salary support to initiate such a research program. Fellowships of between 1-3 years duration will be provided for both postdoctoral fellows and junior faculty members including individuals with training in laboratory science and clinical infectious diseases. Fellows will be recruited from diverse institutions within the Pacific Northwest RCE (PNWRCE) and will be evaluated and selected by a Selection Committee derived from multiple PNWRCE institutions. Fellows will be required to devote 80% effort to the research project, will be paired with a senior faculty mentor, and will be evaluated by the Selection Committee on an annual basis. In addition, fellows will be required to present reports 2 and 4 years following completion of the fellowship to evaluate the effect of the training program on their careers in BA/EID research. A second major component of the training program is to offer courses in 3 areas that will promote essential training related to BA/EID. The first course will provide researchers at the graduate student, postdoctoral, and faculty levels with rigorous training in biohazard safety laboratory practices at the BSL3 level of containment to ensure that they can work effectively with Select Agents. The second course will provide basic training in bioinformatics to individuals from the graduate student through faculty level so that they can design projects and work effectively with collaborators who are experts in bioinformatics. The third course will provide training in emergency response to a BA/EID outbreak and will be targeted at public health trainees, medical students, residents, clinical fellows and basic scientists. Each course will be evaluated annually by questionnaire, by review on the part of the faculty, and by presentation of results to the RCE Steering Committee to judge success and to recommend improvements.

Public Health Relevance

The proposed Career Development and Training program will recruit and train individuals into research on BA/EID thus substantially enhancing the cadre of capable researchers within the Pacific Northwest. The program will both bring new junior researchers into this field and will strengthen the laboratory and theoretical background of researchers from the graduate student to faculty level.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AI081680-03
Application #
8234056
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2011-03-01
Project End
2014-02-28
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
3
Fiscal Year
2011
Total Cost
$523,958
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Kebaabetswe, Lemme P; Haick, Anoria K; Gritsenko, Marina A et al. (2015) Proteomic analysis reveals down-regulation of surfactant protein B in murine type II pneumocytes infected with influenza A virus. Virology 483:96-107
Gralinski, Lisa E; Ferris, Martin T; Aylor, David L et al. (2015) Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross. PLoS Genet 11:e1005504
Okumura, Atsushi; Rasmussen, Angela L; Halfmann, Peter et al. (2015) Suppressor of Cytokine Signaling 3 Is an Inducible Host Factor That Regulates Virus Egress during Ebola Virus Infection. J Virol 89:10399-406
Sanchez, Erica L; Lagunoff, Michael (2015) Viral activation of cellular metabolism. Virology 479-480:609-18
LaBeaud, A Desiree; Banda, Tamara; Brichard, Julie et al. (2015) High rates of o'nyong nyong and Chikungunya virus transmission in coastal Kenya. PLoS Negl Trop Dis 9:e0003436
Rasmussen, Angela L; Tchitchek, Nicolas; Safronetz, David et al. (2015) Delayed inflammatory and cell death responses are associated with reduced pathogenicity in Lujo virus-infected cynomolgus macaques. J Virol 89:2543-52
Fontaine, Krystal A; Sanchez, Erica L; Camarda, Roman et al. (2015) Dengue virus induces and requires glycolysis for optimal replication. J Virol 89:2358-66
Davis, Zoe H; Verschueren, Erik; Jang, Gwendolyn M et al. (2015) Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. Mol Cell 57:349-60
Mirrashidi, Kathleen M; Elwell, Cherilyn A; Verschueren, Erik et al. (2015) Global Mapping of the Inc-Human Interactome Reveals that Retromer Restricts Chlamydia Infection. Cell Host Microbe 18:109-21
Kell, Alison M; Gale Jr, Michael (2015) RIG-I in RNA virus recognition. Virology 479-480:110-21

Showing the most recent 10 out of 122 publications