Hyperthermia induced by magnetic nanoparticles in high frequency alternating magnetic fields (AMF), or Magnetic Fluid Hyperthermia (MFH), is based on the delivery of thermal energy at the nano-scale to tumors using iron oxide based magnetic nanoparticles (MNP) and an externally applied AMF. This phenomenon is the result of particle rotation or movement of the magnetic dipole. The fact that energy is only dissipated under high-frequency and moderate amplitude fields that can be constrained to the tumor region make MFH a highly promising form of non-invasive, externally activated cancer treatment To this date, the prevailing paradigm in the field is that delivery of nanoscale particles to tumors can be achieved by passive targeting due to the enhanced permeation and retention (EPR) effect. However, in vivo experiments tumors suggest otherwise, thus, posing potential limitations on the successful translation of such systems to the clinic. The aforementioned discrepancy reveals a need to understand the in vivo spatial and temporal behavior of nanoparticles as a result of their surface physicochemical properties. To our knowledge, the relationship between surface properties and the resulting temporal and spatial behavior has not been investigated in orthotopic mouse models of cancer. The long-term goal of this project is to develop MNPs as a clinically feasible tool by providing a comprehensive understanding from fundamental particle design to clinical application. The main objective of this proposal is to pursue the optimization ofthe spatial and temporal behavior of Magnetic Nanoparticle Heaters (MNH) and perform an in vivo efficacy assessment of targeted or """"""""intelligent"""""""" (iMNHs) developed in our laboratories forcancer treatment applications. Otyr working hypothesis is that long circulating maonetic nanoparticles withspecific targeting ligands, IMNH, will improve nanopartide delivery to ovarian orthotopic tumors, which willresult in improved therapeutic outcome. This hypothesis was based on preliminary data derived during the """"""""pilot project"""""""" phase, which demonstrated: (1) in vivo nanoparticle's temporal behavior is governed by surface properties, (ii) passive targeting due to the EPR effect may not be sufficient to deliver sufficient particles to the tumor site, and (iii) intelligent targeted nanoparticles have demonstrated significant improvements in treatment efficacy in vitro. The rationale for the proposed research is that once the pharmacokinetics, biodistribution, therapeutic efficacy, and, safety ofthe proposed systems is assessed and understood, future steps can be taken to optimize system's properties thus improving its clinical potential.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
United States
Zip Code
Irizarry-Ramírez, Margarita; Kittles, Rick A; Wang, Xuemei et al. (2017) Genetic ancestry and prostate cancer susceptibility SNPs in Puerto Rican and African American men. Prostate 77:1118-1127
Cruz-Correa, Marcia; Pérez-Mayoral, Julyann; Dutil, Julie et al. (2017) Clinical Cancer Genetics Disparities among Latinos. J Genet Couns 26:379-386
Gökce, Mehmet I; Wang, Xuemei; Frost, Jacqueline et al. (2017) Informed decision making before prostate-specific antigen screening: Initial results using the American Cancer Society (ACS) Decision Aid (DA) among medically underserved men. Cancer 123:583-591
Rodriguez-Aguayo, Cristian; Monroig, Paloma Del C; Redis, Roxana S et al. (2017) Regulation of hnRNPA1 by microRNAs controls the miR-18a-K-RAS axis in chemotherapy-resistant ovarian cancer. Cell Discov 3:17029
Palacios, Cristina; Daniel, Carrie R; Tirado-Gómez, Maribel et al. (2017) Dietary Patterns in Puerto Rican and Mexican-American Breast Cancer Survivors: A Pilot Study. J Immigr Minor Health 19:341-348
Ramírez-Amill, Reinaldo; Soto-Salgado, Marievelisse; Vázquez-Santos, Carla et al. (2017) Assessing Colorectal Cancer Knowledge Among Puerto Rican Hispanics: Implications for Cancer Prevention and Control. J Community Health 42:1141-1147
Colón-López, Vivian; González, Daisy; Vélez, Camille et al. (2017) Community-Academic Partnership to Implement a Breast and Cervical Cancer Screening Education Program in Puerto Rico. P R Health Sci J 36:191-197
Torres, David; Pericchi, Luis R; Mattei, Hernando et al. (2017) Comparative Longterm Mortality Trends in Cancer vs. Ischemic Heart Disease in Puerto Rico. P R Health Sci J 36:55-60
Mama, Scherezade K; Song, Jaejoon; Ortiz, Alexis et al. (2017) Longitudinal social cognitive influences on physical activity and sedentary time in Hispanic breast cancer survivors. Psychooncology 26:214-221
Salgado-Montilla, Jeannette L; Rodríguez-Cabán, Jorge L; Sánchez-García, Jonathan et al. (2017) Impact of FTO SNPs rs9930506 and rs9939609 in Prostate Cancer Severity in a Cohort of Puerto Rican Men. Arch Cancer Res 5:

Showing the most recent 10 out of 108 publications