N5. EDUCATION AND OUTREACH CORE N5A. CANCER SYSTEMS BIOLOGY EDUCATION AT MIT The MIT Tumor Cell Networks Center devotes high priority to training students and postdocs at the interface engaging cancer biology with computational modeling approaches. While our current faculty members are active in this emerging field, the future of cancer biology more critically depends on educating a new generation of scientists to lead advances in this field. Our strategy is to encourage student/postdoc trainees to have joint mentorship from supervisors whose core expertise straddle the computational-biological interface. We endeavor to attract students/postdocs from both molecular/cellular biology and computerscience/ engineering and place them together in joint research projects with faculty members from these two broad areas. N5B. OUTREACH The ICBP grant has had a significant impact within the MIT campus community by catalyzing interactions between the systems biology and cancer biology communities. One example of the new communication between these communities was the choice to focus the annual MIT Center for Cancer Research Symposium on the """"""""Systems Biology of Cancer"""""""" in 2008. The program for this Symposium (with over 1,000 attendees) featured outstanding investigators from a number of institutions across the USA and Canada bringing integrative systems approaches to bear on basic and clinical science facets in fundamental understanding, diagnosis and treatment of cancer. A striking manifestation of our marrying the cancer and systems biology communities was the evolution of the MIT Center for Cancer Research into the new Koch Institute for Integrative Cancer Research - doubled in size, now including a roughly equal number of members from MIT science and engineering departments.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA112967-07
Application #
8234152
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
7
Fiscal Year
2011
Total Cost
$183,275
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Bruno, Peter M; Liu, Yunpeng; Park, Ga Young et al. (2017) A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress. Nat Med 23:461-471
Miller, Miles A; Sullivan, Ryan J; Lauffenburger, Douglas A (2017) Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer. Clin Cancer Res 23:623-629
Werbin, Jeffrey L; Avendaño, Maier S; Becker, Verena et al. (2017) Multiplexed Exchange-PAINT imaging reveals ligand-dependent EGFR and Met interactions in the plasma membrane. Sci Rep 7:12150
Oudin, Madeleine J; Barbier, Lucie; Schäfer, Claudia et al. (2017) MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer. Mol Cancer Ther 16:143-155
Carmona, G; Perera, U; Gillett, C et al. (2016) Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE. Oncogene 35:5155-69
Zhao, Boyang; Sedlak, Joseph C; Srinivas, Raja et al. (2016) Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution. Cell 165:234-246
Gosline, Sara J C; Gurtan, Allan M; JnBaptiste, Courtney K et al. (2016) Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements. Cell Rep 14:310-9
Pirhaji, Leila; Milani, Pamela; Leidl, Mathias et al. (2016) Revealing disease-associated pathways by network integration of untargeted metabolomics. Nat Methods 13:770-6
Tape, Christopher J; Ling, Stephanie; Dimitriadi, Maria et al. (2016) Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. Cell 165:910-20
Oudin, Madeleine J; Miller, Miles A; Klazen, Joelle A Z et al. (2016) MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis. Mol Biol Cell 27:3085-3094

Showing the most recent 10 out of 217 publications