DEVELOPMENTAL COREThe Developmental Core for the DAB Component of the MSM/TU/UABCCC Partnership consists of theDevelopmental Research Program, under which the pilot and full projects are administered, the ResearchTraining and Career Development Program, the Community Outreach Program, the Cancer EducationProgram, and the two Shared Resources, Biostatistics and Bioethics. No recruitment dollars are allocated forUAB.The Developmental Core will be directed by the Pis under the guidance of the IAC. As noted in theAdministrative Core section of this proposal, the co-leaders of the individual programs noted above will providea brief update at the monthly IAC meetings. On a rotating basis, an in-depth presentation and discussion ofthe various programs will provide the IAC with the opportunity to evaluate the Program in some detail andmake suggestions and mid-course corrections as necessary.At UAB, the Lead PI, Dr. Edward Partridge, is responsible for the following programs in the DevelopmentalCore: Developmental Research Program and Biostatistics Shared Resource. Dr. Mona Fouad, PI will beresponsible for the Research Training and Career Development (RTCD), Community Outreach, CancerEducation, and the Bioethics Shared Resource.The Developmental Research Program is responsible for the pilot/full research projects. To that end, thisProgram is responsible for the call for proposals, selection of competitive projects, progress evaluation for theresearch projects, adequacy of mentorship (along with RTCD Program) and advice regarding the pursuit ofexternal funding. Dr. Partridge is the UAB leader of this Program.The Research Training and Career Development Program is responsible for development and implementationof training tracks for postdoctoral fellows, junior faculty, and transitional faculty. We will have training tracks inCommunity-based Participatory Research (CBPR), Cancer Control & Population Science (CCPS), and BasicScience in Cancer Research (BSCR). This Program also contributes to the existing graduate students' annualSummer Cancer Research Training Program (SCRTP) and assists in the administration of the CancerResearch Fellows Program. The leader of this Program at UAB is Dr. Mona Fouad.The Community Outreach Program at UAB is responsible for designing, implementing and refining the CHAPatient Navigator Program to increase participation in clinical trials. Dr. Nedra Lisovicz is the UAB leader ofthis Program, under the direction of Dr. Fouad, PI.The Cancer Education Program is responsible for design, administration, and evaluation of the CancerPartnership Interns Program including selection, advancement, and tracking the interns. The ultimate purposeof the Cancer Partnership Interns is mentored progression to graduate and professional schools. In additionthis Program will develop and implement a new health disparities course that will expand student participants'knowledge of health disparities data, issues, and research. Dr. Michelle Martin will lead the UAB component ofthis Program, under the direction of Dr. Fouad, PI.Two Shared Resources will be included in the Development Core:1. The Bioethics Shared Resource supports all programs in this Partnership. The resource providesbioethical training for mentors, junior and mid-level faculty, postdoctoral fellows, graduate students,undergraduates, community partners, and key Partnership staff. The Bioethics Shared Resource alsoassists in the development and teaching of the Health Disparities Course of the Cancer EducationProgram. In addition the Cancer Education Program is supported by this resource via co-correlationand co-teaching of the Bioscience Research and Ethics Course, and co-mentoring of the CancerPartnership Interns working in health disparities/bioethics projects. In addition, this resource supportsthe Developmental Research Program by initial and periodic bioethical review of the research projects.The Community Outreach and RTCD Programs are supported by substantial bioethical education andtraining programs. The UAB leader for this shared resource is Dr. Patricia Lee, under the direction ofDr. Fouad, PI.2. The Biostatistics Shared Resource provides biostatistical consultation and collective support for thepilot/full research projects in the Developmental Research Program. This includes study design, datamanagement, and statistical analysis. Biostatistical mentorship is also provided to junior investigators.In addition the RTCD Program is supported by this resource which offers training courses inbiostatistics, epidemiology, clinical trials, and bioinformatics. The Community Outreach Program is alsosupported by this resource which is developing a website to disseminate further information related toeach program. Dr. Seng-jaw Soong leads this resource at DAB, under the direction of Dr. Partridge,Lead PI.The programs in the Developmental Core will be vigorously evaluated using the Logic model. Details ofevaluation are presented in each section that follows.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54CA118948-02A1
Application #
7425161
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (O1))
Project Start
2007-12-01
Project End
2011-08-31
Budget Start
2007-12-01
Budget End
2008-08-31
Support Year
2
Fiscal Year
2007
Total Cost
$742,779
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Luo, Yanzhuo; Li, Bingjin; Zhang, Guangxin et al. (2018) Integrated Oncogenomic Profiling of Copy Numbers and Gene Expression in Lung Adenocarcinomas without EGFR Mutations or ALK Fusion. J Cancer 9:1096-1105
Wang, Chiung-Min; Yang, William H; Liu, Runhua et al. (2018) FOXP3 Activates SUMO-Conjugating UBC9 Gene in MCF7 Breast Cancer Cells. Int J Mol Sci 19:
Moore, Justin Xavier; Royston, Kendra J; Langston, Marvin E et al. (2018) Mapping hot spots of breast cancer mortality in the United States: place matters for Blacks and Hispanics. Cancer Causes Control :
Akinyemiju, Tomi; Moore, Justin Xavier; Pisu, Maria et al. (2018) A Prospective Study of Obesity, Metabolic Health, and Cancer Mortality. Obesity (Silver Spring) 26:193-201
Akinyemiju, Tomi; Moore, Justin Xavier; Judd, Suzanne E et al. (2018) Pre-diagnostic biomarkers of metabolic dysregulation and cancer mortality. Oncotarget 9:16099-16109
Piyathilake, Chandrika J; Badiga, Suguna; Borak, Samuel G et al. (2017) A higher degree of expression of DNA methyl transferase 1 in cervical cancer is associated with poor survival outcome. Int J Womens Health 9:413-420
Williams, Samuel K; Braxton, Joanne M; Gosdin, Melissa et al. (2017) Evidence-Based Care for the Elderly: Uses of ""the Grandmother Principle"". J Health Care Poor Underserved 28:7
Gao, Song; Wang, Yicun; Wang, Meng et al. (2017) MicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancer. Oncotarget 8:41451-41464
Jia, Xu; Shanmugam, Chandrakumar; Paluri, Ravi K et al. (2017) Prognostic value of loss of heterozygosity and sub-cellular localization of SMAD4 varies with tumor stage in colorectal cancer. Oncotarget 8:20198-20212
Zhang, Yifan; Li, Bingjin; Zhang, Xingyi et al. (2017) CD24 is a genetic modifier for risk and progression of prostate cancer. Mol Carcinog 56:641-650

Showing the most recent 10 out of 193 publications