Abstract

The goal of the proposed studies is to inform and enhance the search for genetic determinants of common, heritable disease by predicting novel candidate genes, and pathways of interacting gene products, likely to harbor genetic variation that influences susceptibility to, or protection against, development of disease. This study will provide a conduit of candidate genes, and gene-networks, that will be genotyped in large, family-based sample collections of Alzheimer's Disease (AD) and autism plus spectrum disorder (ASD) kindreds, respectively. A second goal is to design and apply appropriate statistical and computational methods to analyze the type of novel genetic datasets that will emerge from the proposed studies, and to identify disease related genetic variants. This will require extensive use of evidence integration methods, biomedical literature datamining, and ontologies developed in Cores 9001 and 9002.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA121852-02
Application #
7311325
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
2
Fiscal Year
2006
Total Cost
$271,660
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Hui, Ken Y; Fernandez-Hernandez, Heriberto; Hu, Jianzhong et al. (2018) Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Sci Transl Med 10:
Azad, Robert N; Zafiropoulos, Dana; Ober, Douglas et al. (2018) Experimental maps of DNA structure at nucleotide resolution distinguish intrinsic from protein-induced DNA deformations. Nucleic Acids Res 46:2636-2647
Abe, Takayuki; Lee, Albert; Sitharam, Ramaswami et al. (2017) Germ-Cell-Specific Inflammasome Component NLRP14 Negatively Regulates Cytosolic Nucleic Acid Sensing to Promote Fertilization. Immunity 46:621-634
Bisikirska, Brygida; Bansal, Mukesh; Shen, Yao et al. (2016) Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression. Cancer Res 76:664-74
Del Giudice, Ilaria; Marinelli, Marilisa; Wang, Jiguang et al. (2016) Inter- and intra-patient clonal and subclonal heterogeneity of chronic lymphocytic leukaemia: evidences from circulating and lymph nodal compartments. Br J Haematol 172:371-383
Wang, Donglai; Kon, Ning; Lasso, Gorka et al. (2016) Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature 538:118-122
Hosios, Aaron M; Hecht, Vivian C; Danai, Laura V et al. (2016) Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Dev Cell 36:540-9
Stockman, Victoria B; Ghamsari, Lila; Lasso, Gorka et al. (2016) A High-Throughput Strategy for Dissecting Mammalian Genetic Interactions. PLoS One 11:e0167617
Alvarez, Mariano J; Shen, Yao; Giorgi, Federico M et al. (2016) Functional characterization of somatic mutations in cancer using network-based inference of protein activity. Nat Genet 48:838-47
Sheng, Ren; Jung, Da-Jung; Silkov, Antonina et al. (2016) Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain. J Biol Chem 291:17639-50

Showing the most recent 10 out of 258 publications