Task Specific Project #1: FDPM Tomography Instrumentation Development for Clinical Deployment The goal of this Task Specific Project will be to build two tomographic FDPM instruments for clinical deployment at MEDVAMC and BTGH for the beginning of year 2. The first year will be spent developing and optimizing the new tomography prototype for efficient manipulation and data acquisition in the Nuclear Imaging Department at MEDVAMC. The next six months of this project will then be spent constructing a second instrument for use in Nuclear Medicine at BTGH. We have already translated an FDPM measurement system from the benchtop to the clinic [69, 71]. Herein, we seek to add surface rendering capabilities as well as to miniaturize and to optimize instrument performance for more practical use in the Nuclear Medicine and in Task Specific Project #2, in the surgical suite.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRRB-9)
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University of Texas Health Science Center Houston
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Rasmussen, John C; Aldrich, Melissa B; Tan, I-Chih et al. (2016) Lymphatic transport in patients with chronic venous insufficiency and venous leg ulcers following sequential pneumatic compression. J Vasc Surg Venous Lymphat Disord 4:9-17
Gonzalez-Garay, M L; Aldrich, M B; Rasmussen, J C et al. (2016) A novel mutation in CELSR1 is associated with hereditary lymphedema. Vasc Cell 8:1
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Gao, Peng; Pinkston, Kenneth L; Wilganowski, Nathaniel et al. (2015) Deglycosylation of mAb by EndoS for improved molecular imaging. Mol Imaging Biol 17:195-203
Rasmussen, John C; Fife, Caroline E; Sevick-Muraca, Eva M (2015) Near-Infrared Fluorescence Lymphatic Imaging in Lymphangiomatosis. Lymphat Res Biol 13:195-201
Ghosh, Sukhen C; Pinkston, Kenneth L; Robinson, Holly et al. (2015) Comparison of DOTA and NODAGA as chelators for (64)Cu-labeled immunoconjugates. Nucl Med Biol 42:177-83
Agollah, Germaine D; Gonzalez-Garay, Manuel L; Rasmussen, John C et al. (2014) Evidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunction. PLoS One 9:e112548
Rasmussen, John C; Herbst, Karen L; Aldrich, Melissa B et al. (2014) An abnormal lymphatic phenotype is associated with subcutaneous adipose tissue deposits in Dercum's disease. Obesity (Silver Spring) 22:2186-92

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