The goal of the trans-network projects is to bring in expertise outside of this PS-OC. If this proposal is successful, then we will immediately begin the work with ether PS-OCs to create mechanisms for developing trans network projects. It is hard to develop these mechanisms with knowing what the other centers will focus on, where they will be, and hew they will be composed. Following the specific NCI guidance (http://physics.cancer.gev/RFA/RFA-CA-09-009-FAQs.asp) and the RFA, we do not propose specific trans-network projects, but rather assert that developing these projects is a key priority for us as a center and we look forward to working with the NCI and our sister PS-OCs to establish a vibrant and scientifically rich set of trans network projects. For example, it will be very important for us to apply our approaches net onlv to breast cancer but also to ether cancers, such as prostate cancer. Ideally, we would thus start a trans-network pilot project with a center focusing en prostate. Part of what we will need to do post-award is to develop processes, mechanisms, and strategies of how trans-network pilot projects will be selected and initiated. We have already discussed approaches for that in our 'within-center' pilot project section. At each opportunity where progress is assessed and plans are discussed, such as at regular meetings of the Executive Committee and the Center Advisory Committee (CAC). and during the Center's annual review, the agenda will include a specific focus on identifying needs for additional areas of expertise, broadening interactions beyond the network, and exposing researchers to alternative and new approaches. Among the benefits of this ongoing dialogue would be the opportunity to identify premising new lines of scientific inquiry that might merit development of new pilots.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Berkeley
United States
Zip Code
Draper, Will; Liphardt, Jan (2017) Origins of chemoreceptor curvature sorting in Escherichia coli. Nat Commun 8:14838
Jorgens, Danielle M; Inman, Jamie L; Wojcik, Michal et al. (2017) Deep nuclear invaginations are linked to cytoskeletal filaments - integrated bioimaging of epithelial cells in 3D culture. J Cell Sci 130:177-189
Miroshnikova, Yekaterina A; Mouw, Janna K; Barnes, J Matthew et al. (2016) Tissue mechanics promote IDH1-dependent HIF1?-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol 18:1336-1345
Chen, Mo; Peters, Alec; Huang, Tao et al. (2016) Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target. Mini Rev Med Chem 16:391-403
Laklai, Hanane; Miroshnikova, Yekaterina A; Pickup, Michael W et al. (2016) Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med 22:497-505
Ou, Guanqing; Thakar, Dhruv; Tung, Jason C et al. (2016) Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integr Biol (Camb) 8:795-804
Gao, Sizhi P; Chang, Qing; Mao, Ninghui et al. (2016) JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors. Sci Signal 9:ra33
Chen, Xingqi; Shen, Ying; Draper, Will et al. (2016) ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing. Nat Methods 13:1013-1020
Ghajar, Cyrus M (2015) Metastasis prevention by targeting the dormant niche. Nat Rev Cancer 15:238-47
Mroue, Rana; Inman, Jamie; Mott, Joni et al. (2015) Asymmetric expression of connexins between luminal epithelial- and myoepithelial- cells is essential for contractile function of the mammary gland. Dev Biol 399:15-26

Showing the most recent 10 out of 129 publications