The goal of the trans-network projects is to bring in expertise outside of this PS-OC. If this proposal is successful, then we will immediately begin the work with ether PS-OCs to create mechanisms for developing trans network projects. It is hard to develop these mechanisms with knowing what the other centers will focus on, where they will be, and hew they will be composed. Following the specific NCI guidance (http://physics.cancer.gev/RFA/RFA-CA-09-009-FAQs.asp) and the RFA, we do not propose specific trans-network projects, but rather assert that developing these projects is a key priority for us as a center and we look forward to working with the NCI and our sister PS-OCs to establish a vibrant and scientifically rich set of trans network projects. For example, it will be very important for us to apply our approaches net onlv to breast cancer but also to ether cancers, such as prostate cancer. Ideally, we would thus start a trans-network pilot project with a center focusing en prostate. Part of what we will need to do post-award is to develop processes, mechanisms, and strategies of how trans-network pilot projects will be selected and initiated. We have already discussed approaches for that in our 'within-center'pilot project section. At each opportunity where progress is assessed and plans are discussed, such as at regular meetings of the Executive Committee and the Center Advisory Committee (CAC). and during the Center's annual review, the agenda will include a specific focus on identifying needs for additional areas of expertise, broadening interactions beyond the network, and exposing researchers to alternative and new approaches. Among the benefits of this ongoing dialogue would be the opportunity to identify premising new lines of scientific inquiry that might merit development of new pilots.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
7U54CA143836-05
Application #
8535640
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$107,265
Indirect Cost
$21,544
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Chen, Mo; Peters, Alec; Huang, Tao et al. (2016) Ras Dimer Formation as a New Signaling Mechanism and Potential Cancer Therapeutic Target. Mini Rev Med Chem 16:391-403
Laklai, Hanane; Miroshnikova, Yekaterina A; Pickup, Michael W et al. (2016) Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med 22:497-505
Gao, Sizhi P; Chang, Qing; Mao, Ninghui et al. (2016) JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors. Sci Signal 9:ra33
Ou, Guanqing; Thakar, Dhruv; Tung, Jason C et al. (2016) Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integr Biol (Camb) 8:795-804
Northcott, Josette M; Northey, Jason J; Barnes, J Matthew et al. (2015) Fighting the force: Potential of homeobox genes for tumor microenvironment regulation. Biochim Biophys Acta 1855:248-53
Nickerson, Andrew; Huang, Tao; Lin, Li-Jung et al. (2015) Photoactivated Localization Microscopy with Bimolecular Fluorescence Complementation (BiFC-PALM). J Vis Exp :e53154
Chang, Ching-Wei; Kumar, Sanjay (2015) Differential Contributions of Nonmuscle Myosin II Isoforms and Functional Domains to Stress Fiber Mechanics. Sci Rep 5:13736
Lee, Somin Eunice; Chen, Qian; Bhat, Ramray et al. (2015) Reversible Aptamer-Au Plasmon Rulers for Secreted Single Molecules. Nano Lett 15:4564-70
Tung, Jason C; Barnes, J Matthew; Desai, Shraddha R et al. (2015) Tumor mechanics and metabolic dysfunction. Free Radic Biol Med 79:269-80
Diamond, Marc I; Cai, Shirong; Boudreau, Aaron et al. (2015) Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1. J Biol Chem 290:9075-86

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