A comprehensive Physics of Cancer Imaging Core (PCIC) will be established within the existing Integrated Imaging Center (IIC), located at Johns Hopkins University Homewood campus to support the investigators of the Center for Cancer Physics. The PCIC will comprise comprehensive microscopy/imaging capabilities including 1) basic epifluorescence and atomic force microscopy;2) ultra-fast/sensitive dynamic live-cell imaging and total internal reflectance fluorescence microscopy (TIRF);3) confocal and multiphoton microscopy;4) fluorescence correlation spectroscopy (FCS);5) multi-mode scanning electron microscopy, including high-vacuum, low-vacuum, and environmental-SEM;6) conventional and high-resolution analytical transmission electron microscopy;and 7) fluorescence-activated cell sorting and analysis (FACS). The PCIC will be sited within the existing IIC in the Dunning Building on the Johns Hopkins Homewood campus. The PCIC will be managed and administered through the existing IIC organizational structure, which has well established protocols for managing equipment;providing training/oversight/access of users;for billing and cost recovery/recharge;and maintains a web-based scheduler which allows for easy reservation of equipment and staff personnel at multiple sites days, weeks, and months in advance. The Imaging Core will be used in all Projects of the Center.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-9)
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Johns Hopkins University
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Park, JinSeok; Kim, Deok-Ho; Kim, Hong-Nam et al. (2016) Directed migration of cancer cells guided by the graded texture of the underlying matrix. Nat Mater 15:792-801
Zhang, Kun; Grither, Whitney R; Van Hove, Samantha et al. (2016) Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts. J Cell Sci 129:1989-2002
He, Lijuan; Chen, Weitong; Wu, Pei-Hsun et al. (2016) Local 3D matrix confinement determines division axis through cell shape. Oncotarget 7:6994-7011
Hielscher, Abigail; Ellis, Kim; Qiu, Connie et al. (2016) Fibronectin Deposition Participates in Extracellular Matrix Assembly and Vascular Morphogenesis. PLoS One 11:e0147600
Ruhland, Megan K; Loza, Andrew J; Capietto, Aude-Helene et al. (2016) Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis. Nat Commun 7:11762
Luo, Xianmin; Fu, Yujie; Loza, Andrew J et al. (2016) Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development. Cell Rep 14:82-92
Lee, Pilhwa; Wolgemuth, Charles W (2016) Physical Mechanisms of Cancer in the Transition to Metastasis. Biophys J 111:256-66
Semenza, Gregg L (2016) Novel strategies for cancer therapy. J Mol Med (Berl) 94:119-20
Semenza, Gregg L (2016) The hypoxic tumor microenvironment: A driving force for breast cancer progression. Biochim Biophys Acta 1863:382-91
Lan, Tian; Cheng, Kai; Ren, Tina et al. (2016) Displacement correlations between a single mesenchymal-like cell and its nucleus effectively link subcellular activities and motility in cell migration analysis. Sci Rep 6:34047

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