This proposal investigates the molecular basis of information flow in cancer cells. The proposed Northwestern University Physical Sciences-Oncology (NU-PSOC) program is organized along a hierarchy of structure and function and consists of five projects areas, each focused on different aspects of the storage and expression of genetic information. Each project integrates methods and ideas of experimental molecular and cell biology with experimental methods and theoretical ideas from the physical sciences to achieve a quantitative and predictive understanding of fundamental mechanisms and principles in the regulation and expression of genes, in normal health and development, and in cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143869-05
Application #
8549127
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O1))
Program Officer
Hanlon, Sean E
Project Start
2009-09-28
Project End
2014-07-31
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$2,285,072
Indirect Cost
$669,719
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Oyer, J A; Huang, X; Zheng, Y et al. (2014) Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies. Leukemia 28:198-201
Ezponda, Teresa; Licht, Jonathan D (2014) Molecular pathways: deregulation of histone h3 lysine 27 methylation in cancer-different paths, same destination. Clin Cancer Res 20:5001-8
Banigan, Edward J; Marko, John F (2014) Torque correlation length and stochastic twist dynamics of DNA. Phys Rev E Stat Nonlin Soft Matter Phys 89:062706
Damania, Dhwanil; Subramanian, Hariharan; Backman, Vadim et al. (2014) Network signatures of nuclear and cytoplasmic density alterations in a model of pre and postmetastatic colorectal cancer. J Biomed Opt 19:16016
Jones, Daniel L; Brewster, Robert C; Phillips, Rob (2014) Promoter architecture dictates cell-to-cell variability in gene expression. Science 346:1533-6
Duncan, Mark T; Shin, Seungjin; Wu, Jia J et al. (2014) Dynamic transcription factor activity profiles reveal key regulatory interactions during megakaryocytic and erythroid differentiation. Biotechnol Bioeng 111:2082-94
Xi, Liqun; Brogaard, Kristin; Zhang, Qingyang et al. (2014) A locally convoluted cluster model for nucleosome positioning signals in chemical map. J Am Stat Assoc 109:48-62
Brewster, Robert C; Weinert, Franz M; Garcia, Hernan G et al. (2014) The transcription factor titration effect dictates level of gene expression. Cell 156:1312-23
Wu, L; Runkle, C; Jin, H-J et al. (2014) CCN3/NOV gene expression in human prostate cancer is directly suppressed by the androgen receptor. Oncogene 33:504-13
Bhattacharyya, Sucharita; Yu, Houqing; Mim, Carsten et al. (2014) Regulated protein turnover: snapshots of the proteasome in action. Nat Rev Mol Cell Biol 15:122-33

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