Abstract

Public Health Relevance

Developed theory of cancer micro-evolution can help to elucidate several phenomena in cancer development. If successful, our study of passenger mutations can offer a potentially novel approach to cancer treatment. This approach use cancers'own internal weakness - numerous accumulated mutations - to bring the population of cancer cells down. Characterization of cancer mutations can provide avenues for dfivfilonment of new anti-cancer driins and heln eluddatina the mechani.sm of action of exciting ones

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54CA143874-01
Application #
7826005
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O1))
Project Start
2009-09-23
Project End
2014-07-31
Budget Start
2009-09-28
Budget End
2010-07-31
Support Year
1
Fiscal Year
2009
Total Cost
$337,725
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Stockslager, Max A; Bagnall, Josephine Shaw; Hecht, Vivian C et al. (2017) Microfluidic platform for characterizing TCR-pMHC interactions. Biomicrofluidics 11:064103
Chen, Xu; Wu, Qiuxia; Depeille, Philippe et al. (2017) RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell 31:685-696.e6
Ramanan, Vyas; Trehan, Kartik; Ong, Mei-Lyn et al. (2016) Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies. Virology 494:236-47
McFarland, Christopher D (2016) A modified ziggurat algorithm for generating exponentially- and normally-distributed pseudorandom numbers. J Stat Comput Simul 86:1281-1294
Hosios, Aaron M; Hecht, Vivian C; Danai, Laura V et al. (2016) Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Dev Cell 36:540-9
Ksionda, O; Melton, A A; Bache, J et al. (2016) RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. Oncogene 35:3658-68
Kimmerling, Robert J; Lee Szeto, Gregory; Li, Jennifer W et al. (2016) A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages. Nat Commun 7:10220
Hecht, Vivian C; Sullivan, Lucas B; Kimmerling, Robert J et al. (2016) Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. J Cell Biol 212:439-47
Stevens, Mark M; Maire, Cecile L; Chou, Nigel et al. (2016) Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate. Nat Biotechnol 34:1161-1167
Akutagawa, J; Huang, T Q; Epstein, I et al. (2016) Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras. Leukemia 30:1335-43

Showing the most recent 10 out of 84 publications