An important part of the Center will be its educational component, which will train students and post-doctoral associates at the interfaces between cancer biology, engineering, and experimental and theoretical physics. While current faculty members are active at these interfaces, the future of cancer biology will be shaped by the trainees who will become the leaders in this emerging area over the next years. We firmly believe that a true integration of different disciplines is best achieved by the joint training and supervision of trainees so that they become deeply conversant with both sides of any interface. Accordingly, we place significant emphasis on efforts to attract students both from cancer biology and from the physical sciences including the engineering disciplines and bring them together in joint research projects with faculty members from these broad areas, which are increasingly yielding productive synergies. MIT has strong research and education programs in the biological sciences on the one hand and in the physical/engineering sciences on the other, as well as strong programs in Biological Engineering and Computational and Systems Biology. There is a large pool of excellent students and MIT already has administrative and educational mechanisms in place for encouraging interdisciplinary activities among these students and the respective faculty members. We have structured our program to leverage this advantageous situation. In addition to allocating slots for student support to individual faculty-led projects, we will assist them in recruiting students through a central pool mechanism. We will explicitly solicit engagement of students from departments of computer science and engineering and the physical sciences. We will offer to the projects, the students who show a strong interest in participating in research activities at the interfaces between the physical sciences and cancer biology, either in the context of research projects under this program or in additional research projects that fit within the mission of the Center. MIT has many faculty members and students in these fields. The core group, that nucleated to prepare this application on the basis of existing collaborations and shared interests, represents only a fraction of the larger group that could be attracted to this interesting, important and timely problem. Already, during the course of planning this program, it has become clear that new collaborations and synergies have developed and much of the research proposed here represents new joint ventures. We believe that the SCDC center will nucleate many similar interactions. In order to increase the pool of interested students and faculty, we will sponsor an open seminar series to bring outside experts, including other PS-OCs members from the network, to MIT to present their research and ideas and meet with faculty and students. This is a very effective form of outreach to increase the interest and involvement of faculty and students from diverse disciplines. We will also support development of new courses within MIT. These courses will be designed to enable students to "cross the boundary" in both directions;helping cancer biologists to become more "numerate" and those from the physics/engineering side to become more conversant with the complexities of cancer biology. From our experience with graduate students, we are well aware that both these educational goals are necessary to produce productive scientists working at the "cancer biology/physics" interface. These educational developments will become publicly available through MIT's Open Courseware (http://ocw.mit.edu) and thus will have impact well beyond our local environment.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143874-05
Application #
8535663
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$92,893
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Almendro, Vanessa; Cheng, Yu-Kang; Randles, Amanda et al. (2014) Inference of tumor evolution during chemotherapy by computational modeling and in situ analysis of genetic and phenotypic cellular diversity. Cell Rep 6:514-27
Semrau, Stefan; Crosetto, Nicola; Bienko, Magda et al. (2014) FuseFISH: robust detection of transcribed gene fusions in single cells. Cell Rep 6:18-23
Knouse, Kristin A; Wu, Jie; Whittaker, Charles A et al. (2014) Single cell sequencing reveals low levels of aneuploidy across mammalian tissues. Proc Natl Acad Sci U S A 111:13409-14
Mizuguchi, Takeshi; Fudenberg, Geoffrey; Mehta, Sameet et al. (2014) Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe. Nature 516:432-5
Barreca, A; Martinengo, C; Annaratone, L et al. (2014) Inter- and intratumoral heterogeneity of BCL2 correlates with IgH expression and prognosis in follicular lymphoma. Blood Cancer J 4:e249
McFarland, Christopher D; Mirny, Leonid A; Korolev, Kirill S (2014) Tug-of-war between driver and passenger mutations in cancer and other adaptive processes. Proc Natl Acad Sci U S A 111:15138-43
Mentink, Remco A; Middelkoop, Teije C; Rella, Lorenzo et al. (2014) Cell intrinsic modulation of Wnt signaling controls neuroblast migration in C. elegans. Dev Cell 31:188-201
Polak, Paz; Lawrence, Michael S; Haugen, Eric et al. (2014) Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair. Nat Biotechnol 32:71-5
Almendro, Vanessa; Kim, Hee Jung; Cheng, Yu-Kang et al. (2014) Genetic and phenotypic diversity in breast tumor metastases. Cancer Res 74:1338-48
Slavov, Nikolai; Budnik, Bogdan A; Schwab, David et al. (2014) Constant growth rate can be supported by decreasing energy flux and increasing aerobic glycolysis. Cell Rep 7:705-14

Showing the most recent 10 out of 48 publications