The Center on the Microenvironment and Metastasis will be operated as a Multi-Institutional Interdisciplinary Research Center managed by Cornell University using established mechanisms and an experienced financial, administration and technical support staff. Our PS-OC organization will incorporate successful process management procedures developed at Cornell. Existing administrative structures and resources, shared research faciiities and underlying technological capabilities will be utilized for this new PS-OC enterprise targeted toward cancer research, Cornell University will be the lead institution of our Center on the Microenvironment and Metastasis. The university has a strong tradition of multi-institutional research organizations and PS-OC faculty and staff will build on this to establish a PS-OC organization that will quickly and effectively support and enhance the research projects of the Center. Our Center will include leaders in the fields of physics, nanobiotechnology, nanotechnology and biomedical engineering at Cornell. Leaders in cancer biology research from V /eill Cornell Medical College in New York City will play a critical role in our Center, as will colleagues at the State University of New Yorkat Buffalo. The Center Advisory Committee will assess overall progress in research, education, and implementation, and partnership development. This assessment will be set in the context of each committee member's area of expertise, as these members collectively will represent the core areas of the center. Key recommendations for future development of the Center will be decided upon by this group, and reports from their meetings will be shared with the Center Director and the Executive Committee We recognize the important role the Physical Sciences-Oncology Centers Steering Committee (PSC) will play in the success of the PS-OC network. Our Center will be represented on this committee by Harold Craighead (Pi/Director) and Barbara Hempstead (senior co-investigator/Co-Director). Our PS-OC representatives on this committee will bring detailed knowledge of progress in our Center's research projects that will enable them to propose and promote collaborations with colleagues at other PS-OCs through trans-Network projects.
This PS-OC brings together expert teams from the fields of physics, nano and microfabrication, engineering and cancer biology to develop novel trans-disciplinary approaches to better understand the complexity of cancer metastasis, the aspect of cancer that directly leads to patient morbidity and mortality. Approaches developed by physical scientists will be focused on the study of cancer. Our studies aim to identify novel mechanisms used by cancer cells, but not normal cells, for growth and metastasis to distant body sites. These new mechanism provide novel drug targets, that aim towards arresting cancer metastasis.
|Thege, Fredrik I; Lannin, Timothy B; Saha, Trisha N et al. (2014) Microfluidic immunocapture of circulating pancreatic cells using parallel EpCAM and MUC1 capture: characterization, optimization and downstream analysis. Lab Chip 14:1775-84|
|Seigel, Gail M (2014) Review: R28 retinal precursor cells: the first 20 years. Mol Vis 20:301-6|
|Hughes, Andrew D; Marshall, Jocelyn R; Keller, Eric et al. (2014) Differential drug responses of circulating tumor cells within patient blood. Cancer Lett 352:28-35|
|Mitchell, Michael J; King, Michael R (2014) Unnatural killer cells to prevent bloodborne metastasis: inspiration from biology and engineering. Expert Rev Anticancer Ther 14:641-4|
|Rhim, Andrew D; Thege, Fredrik I; Santana, Steven M et al. (2014) Detection of circulating pancreas epithelial cells in patients with pancreatic cystic lesions. Gastroenterology 146:647-51|
|Esch, Mandy B; Smith, Alec S T; Prot, Jean-Matthieu et al. (2014) How multi-organ microdevices can help foster drug development. Adv Drug Deliv Rev 69-70:158-69|
|Chandrasekaran, Siddarth; Marshall, Jocelyn R; Messing, James A et al. (2014) TRAIL-mediated apoptosis in breast cancer cells cultured as 3D spheroids. PLoS One 9:e111487|
|Santana, Steven M; Antonyak, Marc A; Cerione, Richard A et al. (2014) Microfluidic isolation of cancer-cell-derived microvesicles from hetergeneous extracellular shed vesicle populations. Biomed Microdevices 16:869-77|
|Congleton, Johanna; Shen, Miaoqing; MacDonald, Robert et al. (2014) Phosphorylation of c-Cbl and p85 PI3K driven by all-trans retinoic acid and CD38 depends on Lyn kinase activity. Cell Signal 26:1589-97|
|Thadani-Mulero, Maria; Portella, Luigi; Sun, Shihua et al. (2014) Androgen receptor splice variants determine taxane sensitivity in prostate cancer. Cancer Res 74:2270-82|
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