PS-OC participants will have access to an extensive array of shared facilities to address the nanobiotechnology and nanofabrication needs of the Center. As the lead institution, Cornell will coordinate much of this core support. The array of capabilities for nanotechnology fabrication, characterization and development and biological imaging on the Cornell campus is unparalleled. Duffield Hall advances research by bringing together nanotechnology related projects in one building near the center of the Ithaca campus, specifically designed to encourage an interactive working environment. The PS-OC administration will be located in Duffield Hall, an ideal location from which to interact with established research centers. We will build on the successes of the Nanobiotechnology Center, which is also housed in Duffield, and through a close partnership with the NBTC, make extensive use of that organization's facilities infrastructure.

Public Health Relevance

This PS-OC brings together expert teams from the fields of physics, nano and microfabrication, engineering and cancer biology to develop novel trans-disciplinary approaches to better understand the complexity of cancer metastasis, the aspect of cancer that directly leads to patient morbidity and mortality. Approaches developed by physical scientists will be focused on the study of cancer. Our studies aim to identify novel mechanisms used by cancer ceils, but not normal cells, for growth and metastasis to distant body sites. These new mechanism provide povel drug targets, that aim towards arresting cancer metastasis.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-9)
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Cornell University
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Thege, Fredrik I; Lannin, Timothy B; Saha, Trisha N et al. (2014) Microfluidic immunocapture of circulating pancreatic cells using parallel EpCAM and MUC1 capture: characterization, optimization and downstream analysis. Lab Chip 14:1775-84
Seigel, Gail M (2014) Review: R28 retinal precursor cells: the first 20 years. Mol Vis 20:301-6
Hughes, Andrew D; Marshall, Jocelyn R; Keller, Eric et al. (2014) Differential drug responses of circulating tumor cells within patient blood. Cancer Lett 352:28-35
Mitchell, Michael J; King, Michael R (2014) Unnatural killer cells to prevent bloodborne metastasis: inspiration from biology and engineering. Expert Rev Anticancer Ther 14:641-4
Rhim, Andrew D; Thege, Fredrik I; Santana, Steven M et al. (2014) Detection of circulating pancreas epithelial cells in patients with pancreatic cystic lesions. Gastroenterology 146:647-51
Esch, Mandy B; Smith, Alec S T; Prot, Jean-Matthieu et al. (2014) How multi-organ microdevices can help foster drug development. Adv Drug Deliv Rev 69-70:158-69
Chandrasekaran, Siddarth; Marshall, Jocelyn R; Messing, James A et al. (2014) TRAIL-mediated apoptosis in breast cancer cells cultured as 3D spheroids. PLoS One 9:e111487
Santana, Steven M; Antonyak, Marc A; Cerione, Richard A et al. (2014) Microfluidic isolation of cancer-cell-derived microvesicles from hetergeneous extracellular shed vesicle populations. Biomed Microdevices 16:869-77
Congleton, Johanna; Shen, Miaoqing; MacDonald, Robert et al. (2014) Phosphorylation of c-Cbl and p85 PI3K driven by all-trans retinoic acid and CD38 depends on Lyn kinase activity. Cell Signal 26:1589-97
Thadani-Mulero, Maria; Portella, Luigi; Sun, Shihua et al. (2014) Androgen receptor splice variants determine taxane sensitivity in prostate cancer. Cancer Res 74:2270-82

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