Our Center's Outreach and Dissemination Unit will provide critical links to the external research community, with special emphasis on researchers in physical sciences and cancer biology. Knowledge, inventions and new capabilities created by our research will be made accessible throughout the Center and applications will be actively promoted in the broader research community and the public and private sectors for the benefit of society. Program elements designed to meet these goals will include: Website;Annual symposium;Seminar series;Research project meetings;Visiting scientist program;Training and workshops.

Public Health Relevance

This PS-OC brings together expert teams from the fields of physics, nano and microfabrication, engineering and cancer biology to develop novel trans-disciplinary approaches to better understand the complexity of cancer metastasis, the aspect of cancer that directly leads to patient morbidity and mortality. Approaches developed by physical scientists will be focused on the study of cancer. Our studies aim to identify novel mechanisms used by cancer cells, but not normal cells, for growth and metastasis to distant body sites. These new mechanism provide novel drug targets, that aim towards arresting cancer metastasis.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143876-05
Application #
8534725
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$92,509
Indirect Cost
Name
Cornell University
Department
Type
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Cao, Xuan; Moeendarbary, Emad; Isermann, Philipp et al. (2016) A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration. Biophys J 111:1541-1552
McCoy, Michael G; Seo, Bo Ri; Choi, Siyoung et al. (2016) Collagen I hydrogel microstructure and composition conjointly regulate vascular network formation. Acta Biomater 44:200-8
Denais, Celine M; Gilbert, Rachel M; Isermann, Philipp et al. (2016) Nuclear envelope rupture and repair during cancer cell migration. Science 352:353-8
Duncan, Sara M; Seigel, Gail M (2016) High-contrast enzymatic immunohistochemistry of pigmented tissues. J Biol Methods 3:
Seigel, G M; Sharma, S; Hackam, A S et al. (2016) HER2/ERBB2 immunoreactivity in human retinoblastoma. Tumour Biol 37:6135-42
Chandrasekaran, Siddarth; Chan, Maxine F; Li, Jiahe et al. (2016) Super natural killer cells that target metastases in the tumor draining lymph nodes. Biomaterials 77:66-76
Wang, Suming; Blois, Anna; El Rayes, Tina et al. (2016) Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment. Sci Transl Med 8:329ra34
Hall, Matthew S; Alisafaei, Farid; Ban, Ehsan et al. (2016) Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs. Proc Natl Acad Sci U S A 113:14043-14048
Bordeleau, Francois; Chan, Bryan; Antonyak, Marc A et al. (2016) Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility. J Biomech 49:1272-9
Levin, Michael; Klar, Amar J S; Ramsdell, Ann F (2016) Introduction to provocative questions in left-right asymmetry. Philos Trans R Soc Lond B Biol Sci 371:

Showing the most recent 10 out of 183 publications