The Education and Training Unit to develop and implement modules for integrative training for graduate and postdoctoral students and junior investigators. ETU will accomplish its mission by leverage the rich training infrastructure available across its collaborating institutions to provide a diverse and engaging experience for trainees. This existing multidisciplinary training infrastructure - which encompasses disciplines as diverse as biology, chemistry, physics and engineering -will provide ETU with: (1) a pool of graduate and postdoctoral trainees, as well as junior and senior investigators who participate as trainees and as mentors;(2) training environments and laboratories for hands-on training;and (3) didactic coursework and internal seminars. ETU will establish a 'Biology, Oncology, Physical Science &Engineering (BiOPSE) track by which trainees can engage in a set of didactic activities, seminars, research rotations in MC-START laboratories and clinical rotations over 2-3 years. We will develop three different sub-tracks within BiOPSE: (1) predoctoral;(2) postdoctoral;(3) junior investigator;and (4) senior investigator. A BiOPSE trainee's course of study will include three (2-year trainees) or six (for 3-year trainees) 2-month research rotations and an optional 1-month clinical rotation. Primary mentors will help structure coursework for trainees to assure that didactic experiences in cancer biology, physics, chemistry, mathematics, computing and engineering. The Banbury Conference Center will host a yearly course for all BiOPSE mentors, trainees, the MC-START Director, senior Co-I and other ETU training faculty. ETU also will utilize a distance learning approach that replies on a state-of-the-art cyberinfrastructure to stimulate development of lasting ties between institutions, schools, departments and centers with different cultures, and in order to enhance the triangulated communications between a trainee and two mentors, to communicate expectations of graduate students and expectations of the student/faculty relationship, and to centralize and make more broadly available critical resources;and mechanisms to exchange trainees among participating institutions.

Public Health Relevance

The Education and Training Unit will plan modules for integrative training and will develop mechanisms to exchange trainees. The orienting principle is to develop a truly multidisciplinary course of training that provides intensive learning experiences in cancer biology, physical sciences and engineering, in order to facilitate the development of a new cadre of researcher with expertise that spans these disciplines.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Los Angeles
United States
Zip Code
Wang, Zhihui; Butner, Joseph D; Kerketta, Romica et al. (2015) Simulating cancer growth with multiscale agent-based modeling. Semin Cancer Biol 30:70-8
Renfrew, P Douglas; Craven, Timothy W; Butterfoss, Glenn L et al. (2014) A rotamer library to enable modeling and design of peptoid foldamers. J Am Chem Soc 136:8772-82
Bendall, Sean C; Davis, Kara L; Amir, El-Ad David et al. (2014) Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. Cell 157:714-25
Gaudillière, Brice; Fragiadakis, Gabriela K; Bruggner, Robert V et al. (2014) Clinical recovery from surgery correlates with single-cell immune signatures. Sci Transl Med 6:255ra131
Wu, Min; Frieboes, Hermann B; Chaplain, Mark A J et al. (2014) The effect of interstitial pressure on therapeutic agent transport: coupling with the tumor blood and lymphatic vascular systems. J Theor Biol 355:194-207
Bruggner, Robert V; Bodenmiller, Bernd; Dill, David L et al. (2014) Automated identification of stratifying signatures in cellular subpopulations. Proc Natl Acad Sci U S A 111:E2770-7
Angelo, Michael; Bendall, Sean C; Finck, Rachel et al. (2014) Multiplexed ion beam imaging of human breast tumors. Nat Med 20:436-42
Holman, Jerry D; Tabb, David L; Mallick, Parag (2014) Employing ProteoWizard to Convert Raw Mass Spectrometry Data. Curr Protoc Bioinformatics 46:13.24.1-9
Wang, Zhihui; Deisboeck, Thomas S; Cristini, Vittorio (2014) Development of a sampling-based global sensitivity analysis workflow for multiscale computational cancer models. IET Syst Biol 8:191-7
Lao, Brooke Bullock; Drew, Kevin; Guarracino, Danielle A et al. (2014) Rational design of topographical helix mimics as potent inhibitors of protein-protein interactions. J Am Chem Soc 136:7877-88

Showing the most recent 10 out of 59 publications