The overall goal of the Partnership for Native American Cancer Prevention (NACP) is to eliminate cancer disparities In Native Americans of the southwest. The University of Arizona Cancer Center (UACC) and Northern Arizona University (NAU) as NACP partner with tribal communities to develop research, outreach, and training activities aimed at defining and eliminating obstacles to health equity in areas of Native American cancer incidence, mortality, and survivorship, and increasing representation in fields that provide the opportunities to overcome these obstacles. The Developmental Core is responsible for overseeing the procedures for development, initial review and ongoing evaluation of research projects that meet the constraints of the NACP, i.e., the project must be collaborative, with co-investigators from NAU and UACC, and with tribal co-investigators when appropriate;the project must be relevant to tribal communities in Arizona;and the project must be relevant to cancer, in terms of defining or addressing issues of cancer disparities, and in providing cancer research training for Native students. The overall goal of the proposed NACP Developmental Core is to foster and support culturally-appropriate research capacity at our institutions both through research projects and through faculty recruitment and development. We will work to increase the number and diversity of researchers at NAU working on cancer related projects, and to increase their research success through Individual Development Plans, as described in the Training Core Program. The Logic Model summarizing these goals is provided in Figure 5. We will work to increase specific outcomes of: (1) Successful external funding for NAU researchers in areas related to cancer and cancer disparities, (2) Peer reviewed publications in areas of cancer research and cancer disparities, (3) Collaborative community interactions through cultural competency training, tribal consultation for project development and dissemination of research results.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54CA143924-06
Application #
8823205
Study Section
Special Emphasis Panel (ZCA1-SRLB-B (O1))
Project Start
2009-09-28
Project End
2019-08-31
Budget Start
2014-09-19
Budget End
2015-08-31
Support Year
6
Fiscal Year
2014
Total Cost
$115,451
Indirect Cost
$59,231
Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Purohit, Rahul; Fritz, Bradley G; The, Juliana et al. (2014) YC-1 binding to the * subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the * subunit. Biochemistry 53:101-14
Gustafson, Heather L; Yao, Song; Goldman, Bryan H et al. (2014) Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma. Am J Hematol 89:639-45
Karn, Robert C; Laukaitis, Christina M (2014) Selection shaped the evolution of mouse androgen-binding protein (ABP) function and promoted the duplication of Abp genes. Biochem Soc Trans 42:851-60
Briehl, Margaret M; Tome, Margaret E; Wilkinson, Sarah T et al. (2014) Mitochondria and redox homoeostasis as chemotherapeutic targets. Biochem Soc Trans 42:939-44
Janousek, Vaclav; Karn, Robert C; Laukaitis, Christina M (2013) The role of retrotransposons in gene family expansions: insights from the mouse Abp gene family. BMC Evol Biol 13:107
Nelson-Moseke, Anna C; Jeter, Joanne M; Cui, Haiyan et al. (2013) An unusual BRCA mutation distribution in a high risk cancer genetics clinic. Fam Cancer 12:83-7
Ramanathan, Saumya; Mazzalupo, Stacy; Boitano, Scott et al. (2011) Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration. Biochemistry 50:7787-99