Previous grant cycles have provided funding for shared instrumentation at Northern Arizona University that has served our laboratory research groups as well as other researchers across the NAU campus. This instrumentation consists of a Leica/McBain confocal microscope, Thermo Fisher Scientific Energy Dispersive X-Ray (EDX) Spectrometer System for the Scanning Electron Microscope, Advanced Microscopic Techniques Digital camera for the Transmission Electron Microscope, Quantachrome Zeta-Reader, and Quantachrome Surface Area Analyzer. This equipment is all housed in the Imaging and Histology Core Facility (IHCF) at NAU and is overseen by a Faculty Manager (Dr. Stearns) and a full-time Assistant Manager (Ms. Aubrey Funke). The investment in these shared resources proved a key element in a successful proposal to the National Science Foundation for Major Research Infrastructure (MRI) funding in 2012 (NSF #1229740, $612,560). Because of our intentional shift to add more community based participatory research to the NACP research portfolio, we do not propose to add more equipment to our shared resources at this time, but rather (1) to provide continued support to the laboratory researchers through funding of a research specialist, (2) to continue providing videoconference access to NAU collaborators of seminars and grant reviews at UACC, and (3) to continue providing access to the UACC shared service facilities to NACP partners at NAU.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-B (O1))
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University of Arizona
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Huynh, Julie M; Laukaitis, Christina M (2016) Panel testing reveals nonsense and missense CDH1 mutations in families without hereditary diffuse gastric cancer. Mol Genet Genomic Med 4:232-6
Bea, J W; Blew, R M; Going, S B et al. (2016) Dual energy X-ray absorptiometry spine scans to determine abdominal fat in postmenopausal women. Am J Hum Biol 28:918-926
Laurila, Kelly; Ingram, Jani C; Briehl, Margaret M et al. (2015) Weaving the Web: Evaluation Strategies to Help Native-American Undergraduate Research Training Programs Navigate Students to Success. CURQ Web 35:4-11
Briehl, Margaret M (2015) Oxygen in human health from life to death--An approach to teaching redox biology and signaling to graduate and medical students. Redox Biol 5:124-39
Trotter 2nd, Robert T; Laurila, Kelly; Alberts, David et al. (2015) A diagnostic evaluation model for complex research partnerships with community engagement: the partnership for Native American Cancer Prevention (NACP) model. Eval Program Plann 48:10-20
Purohit, Rahul; Fritz, Bradley G; The, Juliana et al. (2014) YC-1 binding to the β subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the α subunit. Biochemistry 53:101-14
Karn, Robert C; Chung, Amanda G; Laukaitis, Christina M (2014) Did androgen-binding protein paralogs undergo neo- and/or Subfunctionalization as the Abp gene region expanded in the mouse genome? PLoS One 9:e115454
Gustafson, Heather L; Yao, Song; Goldman, Bryan H et al. (2014) Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma. Am J Hematol 89:639-45
Karn, Robert C; Laukaitis, Christina M (2014) Selection shaped the evolution of mouse androgen-binding protein (ABP) function and promoted the duplication of Abp genes. Biochem Soc Trans 42:851-60
Briehl, Margaret M; Tome, Margaret E; Wilkinson, Sarah T et al. (2014) Mitochondria and redox homoeostasis as chemotherapeutic targets. Biochem Soc Trans 42:939-44

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