Follicular Lymphoma: An Indolent Malignancy That is Incurable. FL arises from a single mature B lymphocyte that has rearranged and expressed a unique set of immunoglobulin heavy and light chain variable region genes, but that also has rearranged and deregulated the expression of the BCL2 anti-apoptotic gene. We suspect that the immunoglobulin B cell receptor transmits growth and survival signals to the developing tumor clone, perhaps from an unidentified antigen stimulus. Through a series of further genetic changes a more malignant subclone can emerge that often results in the death of the patient. During a long indolent phase the tumor can respond to a variety of chemotherapy drugs, radiotherapy treatments and immunological therapies, such as monoclonal antibodies, but the disease is uniformly incurable. There is no suitable animal model for human FL and therefore our understanding of the biology of this malignant disease is necessarily restricted to an analysis of tumor specimens obtained from patients at various stages of the malignant progression.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA149145-05
Application #
8628778
Study Section
Special Emphasis Panel (ZCA1-SRLB-C)
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
5
Fiscal Year
2014
Total Cost
$157,586
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
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