Early Life Estrogenicity and Mammary Cancer Risk. While the timing of estrogen exposures has profound and often opposing effects on breast cancer suscepfibility, the molecular changes and programming that are altered by these exposures are almost entirely unknown. Dr. Hilakivi-Clarke and her team will focus on identifying key transcription factor-based signaling associated with increased mammary cancer risk in the mammary glands of rodents exposed to an elevated estrogenic environment in utero. We will determine the effects of these exposures on altering the sensitivity of the adult gland to E2, and on the endocrine responsiveness of mammary tumors arising in these glands. Data from these studies will be used to build computational models of ER-driven signaling associated with the effects of estrogens on increasing mammary gland susceptibility to neoplastic transformation and on endocrine responsiveness of mammary tumors. These data will also provide and unique powerful insights into the modeling in Projects 1 and 2.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA149147-03
Application #
8377522
Study Section
Special Emphasis Panel (ZCA1-SRLB-C)
Project Start
Project End
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
3
Fiscal Year
2012
Total Cost
$115,643
Indirect Cost
Name
Georgetown University
Department
Type
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
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Beck, Tim N; Smith, Chad H; Flieder, Douglas B et al. (2017) Head and neck squamous cell carcinoma: Ambiguous human papillomavirus status, elevated p16, and deleted retinoblastoma 1. Head Neck 39:E34-E39
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Cook, Katherine L; Schwartz-Roberts, Jessica L; Baumann, William T et al. (2016) Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer. Mol Cell Oncol 3:e1023928
Beck, Tim N; Golemis, Erica A (2016) Genomic insights into head and neck cancer. Cancers Head Neck 1:

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