Nanotechnology has enormous potential for creating innovative cancer diagnostics and therapeutics. This application proposes to establish a new Northwestern University (NU)-based CCNE comprised of a partnership between the Robert H. Lurie Comprehensive Cancer Center and the International Institute for Nanotechnology. This partnership will leverage and build upon significant existing resources, relationships, and traditions of cross-disciplinary collaborations. NU is one of the few universities with the required physical infrastructure and intellectual capacity, a demonstrated track record of research success and technology transfer in nanotechnology, and established links between nanoscientists and cancer researchers to successfully achieve the stated objectives of a CCNE. The goal of this CCNE is to advance nanotechnology discoveries that have potential clinical utility for brain, pancreatic, and breast cancer detection, diagnosis, and treatment. Under the co-leadership of Chad A. Mirkin, who will drive the nanotechnology effort, and Steven Rosen, who will drive the clinical translational oncology effort, research is organized into five multidisciplinary teams. These teams are comprised of nanoscientists, cancer biologists, engineers, and clinicians with the goal of developing novel nanoscale technologies for ultimate development as cancer diagnostics, imaging agents, and therapeutics. Each project has a distinct focus and an industrial partner to promote the development of a platform for application in the clinic. To support these research goals, three Shared Resource Cores will be established: a Nanoconstructs Core to synthesize and characterize new nanotechnology constructs, which can feed into the primary projects and be tested in a common set of cell and animal models;a Bioinformatics Core to expand current biocomputing capabilities and to provide the capacity to utilize NCI online resources;and an Administrative Core to manage budgetary, administrative, and outreach matters. The NU-CCNE will promote collaborations not only across research projects within the center, but also Alliance-wide through pilot projects that will foster an environment where progress in one area could serve as a catalyst for progress in another.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA151880-02
Application #
8145721
Study Section
Special Emphasis Panel (ZCA1-GRB-S (M1))
Program Officer
Grodzinski, Piotr
Project Start
2010-09-21
Project End
2015-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
2
Fiscal Year
2011
Total Cost
$2,329,637
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Lee, Dong-Keun; Kee, Theodore; Liang, Zhangrui et al. (2017) Clinical validation of a nanodiamond-embedded thermoplastic biomaterial. Proc Natl Acad Sci U S A 114:E9445-E9454
Rammohan, Nikhil; Holbrook, Robert J; Rotz, Matthew W et al. (2017) Gd(III)-Gold Nanoconjugates Provide Remarkable Cell Labeling for High Field Magnetic Resonance Imaging. Bioconjug Chem 28:153-160
McMahon, Kaylin M; Scielzo, Cristina; Angeloni, Nicholas L et al. (2017) Synthetic high-density lipoproteins as targeted monotherapy for chronic lymphocytic leukemia. Oncotarget 8:11219-11227
Sita, Timothy L; Kouri, Fotini M; Hurley, Lisa A et al. (2017) Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivo. Proc Natl Acad Sci U S A 114:4129-4134
Scott, Alexander W; Garimella, Viswanadham; Calabrese, Colin M et al. (2017) Universal Biotin-PEG-Linked Gold Nanoparticle Probes for the Simultaneous Detection of Nucleic Acids and Proteins. Bioconjug Chem 28:203-211
Chinen, Alyssa B; Guan, Chenxia M; Ko, Caroline H et al. (2017) The Impact of Protein Corona Formation on the Macrophage Cellular Uptake and Biodistribution of Spherical Nucleic Acids. Small 13:
Banga, Resham J; Krovi, Sai Archana; Narayan, Suguna P et al. (2017) Drug-Loaded Polymeric Spherical Nucleic Acids: Enhancing Colloidal Stability and Cellular Uptake of Polymeric Nanoparticles through DNA Surface-Functionalization. Biomacromolecules 18:483-489
Hendricks, Mark P; Sato, Kohei; Palmer, Liam C et al. (2017) Supramolecular Assembly of Peptide Amphiphiles. Acc Chem Res 50:2440-2448
Hung, Andy H; Lilley, Laura M; Hu, Fengqin et al. (2017) Magnetic barcode imaging for contrast agents. Magn Reson Med 77:970-978
Hong, Christine; Song, Dayoung; Lee, Dong-Keun et al. (2017) Reducing posttreatment relapse in cleft lip palatal expansion using an injectable estrogen-nanodiamond hydrogel. Proc Natl Acad Sci U S A 114:E7218-E7225

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