Drawing on the broad scientific expertise of faculty at Washington University in St. Louis and collaborators and consultants from other institutions, we propose to build on existing transdisciplinary approaches and create a center to address mechanisms of obesity and cancer, "from cell to society". We include projects that move beyond traditional risk factor-cancer associations to look at multilevel and multigenerational associations as well as the interaction of traditional cancer risk behaviors. We leverage the unique opportunity Missouri provides to study human populations given its diversity across race/ethnicity and socioeconomic status. We will delineate mechanisms by which preconception diet, nutrition &built environment polices impact inactivity and physical activity and energy balance to influence body weight and carcinogenesis across the life course. Specifically we aim to: 1. Investigate in a mouse model the effect of maternal high fat diet and changes in metabolic bioenergetics on prostate gland development and susceptibility to prostate cancer in male mouse offspring; 2. Study the role of physical activity and obesity in post-prostatectomy urinary and sexual function; 3. Develop models of obesity across the life course and generations incorporating biologic, clinical and social determinants of risk and mortality, which can be applied to different cancer outcomes, using non-Hodgkin Lymphoma as the initial platform; 4. Study policies relating to nutrition and built environment that impact energy balance and obesity; 5. Train postdoctoral fellows in a transdisciplinary environment to pursue careers in energetics and cancer and expose scholars from across our university to transdisciplinary work in obesity and cancer; 6. Foster scientific synergy via smaller-scale innovative transdisciplinary research that builds on the Center's theme and resources;and 7. Maximize efficiency and productivity of TREC-related studies and cores by building an outstanding transdisciplinary center supported by outstanding administrative, budgetary, and technology resources. To address these aims, we propose four research projects and five cores that form a cohesive, transdisciplinary center focused on research, training/career development, and dissemination.
This Center will bring new approaches to understanding both genetic and social determinants and obesity across generations. Importantly the Center research addresses obesity and physical inactivity influence cancer outcomes, including among cancer survivors, and extends study of obesity and treatment outcomes to Non-Hodgkin Lymphoma, an increasingly common malignancy. Together these studies will inform policy and practice to prevent obesity and reduce the burden of cancer due to obesity.
|Tabak, Rachel G; Hipp, J Aaron; Marx, Christine M et al. (2016) Which worksite supports for healthy weight do employees use? Environ Behav 48:131-149|
|Schmitz, Kathryn H; Gehlert, Sarah; Patterson, Ruth E et al. (2016) TREC to WHERE? Transdisciplinary Research on Energetics and Cancer. Clin Cancer Res 22:1565-71|
|Moley, Kelle H; Colditz, Graham A (2016) Effects of obesity on hormonally driven cancer in women. Sci Transl Med 8:323ps3|
|Yaghjyan, Lusine; Carlsson, Nils P; Ghita, Gabriela L et al. (2016) Associations of individual characteristics and lifestyle factors with metabolism of di-2-ethylhexyl phthalate in NHANES 2001-2012. Environ Res 149:23-31|
|Yaghjyan, Lusine; Ghita, Gabriela L; Dumont-Driscoll, Marilyn et al. (2016) Maternal exposure to di-2-ethylhexylphthalate and adverse delivery outcomes: A systematic review. Reprod Toxicol 65:76-86|
|Mitchell, Jonathan A; Godbole, Suneeta; Moran, Kevin et al. (2016) No Evidence of Reciprocal Associations between Daily Sleep and Physical Activity. Med Sci Sports Exerc 48:1950-6|
|Arroyo-Johnson, Cassandra; Mincey, Krista D; Ackermann, Nicole et al. (2016) Racial and Ethnic Heterogeneity in Self-Reported Diabetes Prevalence Trends Across Hispanic Subgroups, National Health Interview Survey, 1997-2012. Prev Chronic Dis 13:E10|
|Colditz, Graham A; Gehlert, Sarah; Bowen, Deborah J et al. (2016) Toward a Modern Science of Obesity at Washington University: How We Do It and What is the Payoff? Cancer Prev Res (Phila) 9:503-8|
|Dodson, Elizabeth Anne; Hipp, James Aaron; Gao, Mengchao et al. (2016) The Impact of Worksite Supports for Healthy Eating on Dietary Behaviors. J Occup Environ Med 58:e287-93|
|Tabak, Rachel; Hipp, J Aaron; Dodson, Elizabeth A et al. (2016) Exploring associations between perceived home and work neighborhood environments, diet behaviors, and obesity: Results from a survey of employed adults in Missouri. Prev Med Rep 4:591-596|
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