Breast cancer related lymphedema (BCRL), characterized by arm swelling, impaired function and bothersome symptoms, is a common, persistent, often progressive adverse event of breast cancer diagnosis and therapy, exacerbated by obesity and sedentary lifestyle. The WISER Survivor Trial (Project 2) will assess in a multi-ethnic cohort of ovenweight and obese post-menopausal women witht BCRL the incremental clinicai effectiveness (lymphedema flares, cellulitis, quality of life) of exercise only, weight loss only, and exercise and weight-loss combined compared with a usual care control group. While BCRL incurs substantial health care costs (significant portions of which are borne by patients), reduces productivity and reduces quality of life, empirical data are sparse. Effective behavioral interventions such as exercise training and weight loss that temporize BCRL, mitigate its impact and prevent progression often are not reimbursed;third party payers rarely cover supplies required to mitigate BCRL. As a consequence, the current insurance structure perversely places breast cancer survivors at needless risk of BCRL adverse events and sequellae and may increase costs as a result of increased downstream complications (e.g., outpatient care and hospitalizations for repeated episodic lymphangitis and cellulitis;physical therapy for BRCL flares and symptomatic exacerbations). Thus, there is a compelling need to better characterize the medical economic impact of BCRL, as well as its short- and long-term health consequences. Project 3 will;(1) assess BCRL direct medical care costs;(2) assess the incremental cost-effectiveness of the Project 2 WISER Survivor interventions;and (3) model the impact ofthe WISER Survivor interventions over an extended time frame. The novel methodological approaches developed to define and identify BCRL cases combining and integrating data from patient reports, administrative claims and national language queries of electronic medical records will inform criteria to identify and select BCRL patients for future studies, as well as establish the validity of alternative methods, while demonstrating the feasibility and potential value of this approach for other medical conditions.

Public Health Relevance

The rigorous within trial collection of medical and productivity costs, quality of life and patient utilities for the outcomes ofthe interventions evaluated in Project 2, in conjunction with decision modeling of expected effects over an extended time period, will provide the most valid and generalizable estimates of BCRL's economic burden and the incremental cost-effectiveness of the BCRL interventions evaluated in Project 2, thus informing public and private insurance reimbursement decisions and policy.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-4)
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University of Pennsylvania
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Brown, Justin C; Kumar, Anagha; Cheville, Andrea L et al. (2015) Association between lymphedema self-care adherence and lymphedema outcomes among women with breast cancer-related lymphedema. Am J Phys Med Rehabil 94:288-96
Sturgeon, Kathleen; Schadler, Keri; Muthukumaran, Geetha et al. (2014) Concomitant low-dose doxorubicin treatment and exercise. Am J Physiol Regul Integr Comp Physiol 307:R685-92
Sturgeon, Kathleen M; Ky, Bonnie; Libonati, Joseph R et al. (2014) The effects of exercise on cardiovascular outcomes before, during, and after treatment for breast cancer. Breast Cancer Res Treat 143:219-26
Brown, Justin C; Schmitz, Kathryn H (2014) The prescription or proscription of exercise in colorectal cancer care. Med Sci Sports Exerc 46:2202-9
Brown, Justin C; Lin, Lilie L; Segal, Saya et al. (2014) Physical activity, daily walking, and lower limb lymphedema associate with physical function among uterine cancer survivors. Support Care Cancer 22:3017-25
Hammer, Sean M; Brown, Justin C; Segal, Saya et al. (2014) Cancer-related impairments influence physical activity in uterine cancer survivors. Med Sci Sports Exerc 46:2195-201
James, Peter; Berrigan, David; Hart, Jaime E et al. (2014) Effects of buffer size and shape on associations between the built environment and energy balance. Health Place 27:162-70
Brown, Justin C; Mao, Jun J; Stricker, Carrie et al. (2014) Aromatase inhibitor associated musculoskeletal symptoms are associated with reduced physical activity among breast cancer survivors. Breast J 20:22-8
Brown, Justin C; Cheville, Andrea L; Tchou, Julia C et al. (2014) Prescription and adherence to lymphedema self-care modalities among women with breast cancer-related lymphedema. Support Care Cancer 22:135-43
Schmitz, Kathryn H; Neuhouser, Marian L; Agurs-Collins, Tanya et al. (2013) Impact of obesity on cancer survivorship and the potential relevance of race and ethnicity. J Natl Cancer Inst 105:1344-54

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