The North Carolina Central University (NCCU) and the Lineberger Comprehensive Cancer Center (LCCC) at the University of North Carolina Chapel Hill (UNC-CH) propose to continue an effective, sustainable, and mutually beneficial partnership in Cancer Research that focuses on African-American health disparities. During the past eight years and with funding from the NCI, the two institutions have firmly established the Partnership by building on complementary instituflonal strengths, conducting joint planning in molecular cancer research, population-based research and training of junior faculty and students. The Partnership now proposes to expand these iniflaflves through an NCI-funded Cooperative Planning Grant (U54) for Comprehensive Partnerships to Reduce Cancer Health Disparities. Our objecflves are: (1) To expand research collaborations among the two institutions;(2) To use research activities in and outside the U54 mechanism to train students and junior/mid-level faculty in mulfldisciplinary research aimed at reducing cancer disparities;and (3) To expand and consolidate programs of community outreach and education. The strengths of each institution are uniquely posifloned to overcome the weaknesses found in the other to achieve these priorities. Specific collaborative components of the proposal include: 3 full projects in basic cancer research, one full and two pilot projects in community outreach, one minority training project, and one shared resource to enhance NCCU infrastructure and the partnership. The extensive expertise, and resources of LCCC in cancer research and cancer education training, the demonstrated interest in minority health disparities and the experience of NCCU in reaching minority populaflons, faculty and students, are complementary institutional strengths that will help the Partnership: 1) establish an effective cancer research infrastructure/program and increase training opportunities at a minority serving institution;and 2) enhance community- and populaflon-based research targeting minority cancer-related health disparities and increase training ef minority scienflsts at an NCI-funded Comprehensive Cancer Center.

Public Health Relevance

African-Americans suffer a disproportionate share ofthe cancer burden, with overall cancer mortality rate averaging one third higher than Caucasian Americans. Furthermore, for cancers such as prostate or cervical cancer where treatment can be effective, the rates of treatment failure or recurrence are higher in African Americans. This partnership will help address these health disparities by promoflng minority-targeted research, and by developing the research infrastructure, capacity, and effectiveness of NCUU.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA156735-04
Application #
8547628
Study Section
Special Emphasis Panel (ZCA1-SRLB-3 (O1))
Program Officer
Moten, Carmen P
Project Start
2010-09-29
Project End
2015-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
4
Fiscal Year
2013
Total Cost
$797,962
Indirect Cost
$360,806
Name
North Carolina Central University
Department
None
Type
Organized Research Units
DUNS #
783691801
City
Durham
State
NC
Country
United States
Zip Code
27707
House, Alan J; Daye, Laura R; Tarpley, Michael et al. (2015) Design and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form. Arch Biochem Biophys 567:66-74
Kong, Ren; Liu, Timothy; Zhu, Xiaoping et al. (2014) Old drug new use--amoxapine and its metabolites as potent bacterial ?-glucuronidase inhibitors for alleviating cancer drug toxicity. Clin Cancer Res 20:3521-30
Chen, Huadong; Fu, Junsheng; Chen, Hao et al. (2014) Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo. Chem Res Toxicol 27:1575-85
Reaves, Denise K; Fagan-Solis, Katerina D; Dunphy, Karen et al. (2014) The role of lipolysis stimulated lipoprotein receptor in breast cancer and directing breast cancer cell behavior. PLoS One 9:e91747
Ren, Dongren; Zheng, Gaolin; Bream, Susan et al. (2014) Single nucleotide polymorphisms of caudal type homeobox 1 and 2 are associated with Barrett's esophagus. Dig Dis Sci 59:57-63
Singh, Vandana; Raghuwanshi, Sandeep K; Smith, Nikia et al. (2014) G Protein-coupled receptor kinase-6 interacts with activator of G protein signaling-3 to regulate CXCR2-mediated cellular functions. J Immunol 192:2186-94
Tarpley, Mike; Abdissa, Temesgen T; Johnson, Gary L et al. (2014) Bosutinib reduces the efficacy of Dasatinib in triple-negative breast cancer cell lines. Anticancer Res 34:1629-35
Wordlaw-Stinson, LaShawn; Jones, Sierra; Little, Shaneese et al. (2014) Challenges and Recommendations to Recruiting Women Who Do Not Adhere to Follow-Up Gynecological Care. Open J Prev Med 4:123-128
Chen, Hao; Hu, Yuhui; Fang, Yu et al. (2014) Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium. Gut 63:711-9
Spruiell, Krisstonia; Richardson, Ricardo M; Cullen, John M et al. (2014) Role of pregnane X receptor in obesity and glucose homeostasis in male mice. J Biol Chem 289:3244-61

Showing the most recent 10 out of 20 publications