Little is known about Barretts esophagus (BE) in terms of its etiology, although it is most likely caused by the complex interplay between genes and environmental factors and it is known to be a direct precursor to Esophageal cancer (EAC). Therefore, large-scale research projects, such as the ones proposed in this BETRNet Translational Research Center (TRC) application, are necessary to have an impact on early detection, diagnosis and prevention. We will develop a centralized Bioinformatics Core infrastructure to support data management, study design, and statistical/bioinformatic analysis for all proposed projects and to help facilitate data sharing and the capacity to link and share data and biospecimens with the BETRNet Data Coordination Center. This Core will meet the requirements for both this application as a whole, for each individual project within this application and for cross-pollination between this TRC and the other funded TRCs under this RFA, leading to many scientific manuscripts and submission of additional grants and pilot projects. Matching the theme and structure of the components of this multi-institutional TRC proposal, this Bioinformatics Core is drawn from faculty at the Case Comprehensive Cancer Center, the Department of Epidemiology and Biostatistics and the Department of Genetics at the Case Western Reserve University (CWRU) School of Medicine, the Department of Public Health Sciences at the Fred Hutchinson Cancer Research Center at the University of Washington and the Department of Biostatistics at the University of North Carolina School of Medicine.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163060-04
Application #
8721889
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Fecteau, Ryan E; Kong, Jianping; Kresak, Adam et al. (2016) Association Between Germline Mutation in VSIG10L and Familial Barrett Neoplasia. JAMA Oncol 2:1333-1339
Sun, Xiangqing; Elston, Robert C; Barnholtz-Sloan, Jill S et al. (2016) Predicting Barrett's Esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm. Cancer Epidemiol Biomarkers Prev 25:727-35
Sun, Xiangqing; Elston, Robert; Falk, Gary W et al. (2016) Linkage and related analyses of Barrett's esophagus and its associated adenocarcinomas. Mol Genet Genomic Med 4:407-19
Curtius, Kit; Wong, Chao-Jen; Hazelton, William D et al. (2016) A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus. PLoS Comput Biol 12:e1004919
Kaz, Andrew M; Wong, Chao-Jen; Varadan, Vinay et al. (2016) Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use. Clin Epigenetics 8:111
Blum, Andrew E; Venkitachalam, Srividya; Guo, Yan et al. (2016) RNA Sequencing Identifies Transcriptionally Viable Gene Fusions in Esophageal Adenocarcinomas. Cancer Res 76:5628-5633
Krishnamoorthi, Rajesh; Borah, Bijan; Heien, Herbert et al. (2016) Rates and predictors of progression to esophageal carcinoma in a large population-based Barrett's esophagus cohort. Gastrointest Endosc 84:40-46.e7
Fiuza-Luces, C; Simpson, R J; Ramírez, M et al. (2016) Physical function and quality of life in patients with chronic GvHD: a summary of preclinical and clinical studies and a call for exercise intervention trials in patients. Bone Marrow Transplant 51:13-26
Cummings, Linda C; Kou, Tzuyung Doug; Schluchter, Mark D et al. (2016) Outcomes after endoscopic versus surgical therapy for early esophageal cancers in an older population. Gastrointest Endosc 84:232-240.e1
Kong, Jianping; Whelan, Kelly A; Laczkó, Dorottya et al. (2016) Autophagy levels are elevated in barrett's esophagus and promote cell survival from acid and oxidative stress. Mol Carcinog 55:1526-1541

Showing the most recent 10 out of 52 publications