Despite increases in cervical cancer screening in the past few decades, African American women have substantially higher rates of cervical cancer incidence and mortality than white women. Persistent infection with high-risk types 16 and 18 of human papillomavirus (HPV) is known to cause 70% of cervical cancers. Since 2006 the FDA has approved two vaccines developed to prevent cervical cancer caused by these high-risk types of genital HPV. Clinical trials have demonstrated these vaccines to be nearly 100% efficacious in preventing infection of HPV types 16 and 18, precancerous cervical disease, and resulting cervical cancer. According to the 2009 National Immunization Survey, rates of initiation of the HPV vaccine were similar for African American and white girls (44%), but rates of completion of the three required doses were lower for African American versus White girls (23% and 29%, respectively). Increasing uptake and completion of the HPV vaccine series among African American girls will reduce rates of cervical cancer among African American women, which in combination with continued Pap testing, can eventually reduce racial disparities in cervical cancer. As a hypothesis-driven research project under the Cancer Outreach Core, we propose to develop and test the feasibility and impact of a culturally-appropriate social marketing intervention targeting African American girls and their parents to increase utilization and completion of the HPV vaccine series. The proposed project follows the model of Community-Based Prevention Marketing as described by Bryant and colleagues, which combines social marketing theories and techniques with community-based participatory research approaches to guide the planning and implementation of evidence-based strategies for addressing public health concerns.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-SRLB-Y)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Meharry Medical College
United States
Zip Code
Brown, Shyretha; Whalen, Margaret (2015) Tributyltin alters secretion of interleukin 1 beta from human immune cells. J Appl Toxicol 35:895-908
Vaiopoulou, Anna; Gazouli, Maria; Papadopoulou, Aggeliki et al. (2015) Serum protein profiling of adults and children with Crohn disease. J Pediatr Gastroenterol Nutr 60:42-7
Sanderson, Maureen; O'Hara, Heather; Foderingham, Nia et al. (2015) Type 2 diabetes and mammographic breast density among underserved women. Cancer Causes Control 26:303-9
Khabele, Dineo; Kabir, Syeda M; Dong, Yuanlin et al. (2014) Preferential effect of akt2-dependent signaling on the cellular viability of ovarian cancer cells in response to EGF. J Cancer 5:670-8
Myers, Jeremy N; Schäffer, Michael W; Korolkova, Olga Y et al. (2014) Implications of the colonic deposition of free hemoglobin-? chain: a previously unknown tissue by-product in inflammatory bowel disease. Inflamm Bowel Dis 20:1530-47
Li, Bo; Lu, Wenfu; Chen, Zhenbang (2014) Regulation of Androgen Receptor by E3 Ubiquitin Ligases: for More or Less. Receptors Clin Investig 1:
Nangami, Gladys; Koumangoye, Rainelli; Shawn Goodwin, J et al. (2014) Fetuin-A associates with histones intracellularly and shuttles them to exosomes to promote focal adhesion assembly resulting in rapid adhesion and spreading in breast carcinoma cells. Exp Cell Res 328:388-400
Patel, Kushal; Kanu, Mohamed; Liu, Jianguo et al. (2014) Factors influencing breast cancer screening in low-income African Americans in Tennessee. J Community Health 39:943-50
Rekhadevi, P V; Diggs, D L; Huderson, A C et al. (2014) Metabolism of the environmental toxicant benzo(a)pyrene by subcellular fractions of human ovary. Hum Exp Toxicol 33:196-202
Li, Bo; Lu, Wenfu; Yang, Qing et al. (2014) Skp2 regulates androgen receptor through ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate cancer. Prostate 74:421-32

Showing the most recent 10 out of 18 publications