A major strength of this proposal is the blending of the complementary expertise of the two labs in breast and colorectal cancer with a shared interest in exosomes, enabling the formation of a true partnership to establish a clinically applicable method to measure selected proteins in exosomes from the serum of cancer patients. We anticipate that the reliable detection and precise quantification of selected proteins in serum exosomes may enable the eariier diagnosis of patients with breast and colorectal cancer. However, the pilot project will establish normal standards for serum exosomes in normal individuals, and then, initially, compare these results to patients with early and advanced colorectal cancer and advanced breast cancer. As the work progresses, analysis of serum exosomes may prove to have prognostic and predictive value in the management of patients with cancer [1].

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163072-02
Application #
8380458
Study Section
Special Emphasis Panel (ZCA1-SRLB-Y)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
2
Fiscal Year
2012
Total Cost
$62,115
Indirect Cost
$22,298
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
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