A major strength of this proposal is the blending of the complementary expertise of the two labs in breast and colorectal cancer with a shared interest in exosomes, enabling the formation of a true partnership to establish a clinically applicable method to measure selected proteins in exosomes from the serum of cancer patients. We anticipate that the reliable detection and precise quantification of selected proteins in serum exosomes may enable the eariier diagnosis of patients with breast and colorectal cancer. However, the pilot project will establish normal standards for serum exosomes in normal individuals, and then, initially, compare these results to patients with early and advanced colorectal cancer and advanced breast cancer. As the work progresses, analysis of serum exosomes may prove to have prognostic and predictive value in the management of patients with cancer [1].

Agency
National Institute of Health (NIH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163072-04
Application #
8724442
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37212
Nichols, Erin E; Richmond, Ann; Daniels, Anthony B (2016) Tumor Characteristics, Genetics, Management, and the Risk of Metastasis in Uveal Melanoma. Semin Ophthalmol 31:304-9
Nichols, Erin E; Richmond, Ann; Daniels, Anthony B (2016) Disparities in Uveal Melanoma: Patient Characteristics. Semin Ophthalmol 31:296-303
Moore, Kelly L; Fankhauser, Melissa K; Hull, Pamela C (2016) Tennessee's 3-Star Report: Using Available Data Systems to Reduce Missed Opportunities to Vaccinate Preteens. Biomed Inform Insights 8:15-21
Wanjala, Jackie; Taylor, Barry S; Chapinski, Caren et al. (2015) Identifying actionable targets through integrative analyses of GEM model and human prostate cancer genomic profiling. Mol Cancer Ther 14:278-88
Brown, Shyretha; Whalen, Margaret (2015) Tributyltin alters secretion of interleukin 1 beta from human immune cells. J Appl Toxicol 35:895-908
Vaiopoulou, Anna; Gazouli, Maria; Papadopoulou, Aggeliki et al. (2015) Serum protein profiling of adults and children with Crohn disease. J Pediatr Gastroenterol Nutr 60:42-7
Sanderson, Maureen; O'Hara, Heather; Foderingham, Nia et al. (2015) Type 2 diabetes and mammographic breast density among underserved women. Cancer Causes Control 26:303-9
Chen, Zhenbang; Lu, Wenfu (2015) Roles of ubiquitination and SUMOylation on prostate cancer: mechanisms and clinical implications. Int J Mol Sci 16:4560-80
Bates, Andreia L; Pickup, Michael W; Hallett, Miranda A et al. (2015) Stromal matrix metalloproteinase 2 regulates collagen expression and promotes the outgrowth of experimental metastases. J Pathol 235:773-83
Lu, Wenfu; Liu, Shenji; Li, Bo et al. (2015) SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. Oncotarget 6:771-88

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