Overview of the Resource. Given the inherent difficulties in obtaining large quantities of tissues from pancreatic cancer patients, we have devised and instituted a rapid autopsy program that is designed to harvest primary tumor and organs containing all metastatic deposits of tumor from individuals who die of pancreatic cancer. The process we have instituted allows us to harvest and rapidly freeze these tissues in a process that is completed within 5 hours of death. This process is unique and highly innovative as a tissue resource in that it allows us to capture the entire history disease progression for pancreatic cancer patients (from intact primary tumor and remaining precursor lesions through to distant metastases at all locations). For the purposes of this application, the resource will provide high quality frozen samples, slides for frozen sections, formalin fixed tissues, and associated body fluids (blood, serum, ascites) for all projects requiring tissues. The costs of acquiring these tissues in the rapid autopsy program are supported in part by our Cancer Center Support Grant and our Pancreatic Cancer SPORE Grant. The costs requested here are supplemental to that support and are required for the requisite sample processing and pathology support that is associated with supporting the projects proposed in this application.

National Institute of Health (NIH)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1)
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University of Nebraska Medical Center
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Macha, M A; Rachagani, S; Pai, P et al. (2015) MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway. Oncogene 34:1698-708
Wakaskar, Rajesh R; Bathena, Sai Praneeth R; Tallapaka, Shailendra B et al. (2015) Peripherally cross-linking the shell of core-shell polymer micelles decreases premature release of physically loaded combretastatin A4 in whole blood and increases its mean residence time and subsequent potency against primary murine breast tumors after I Pharm Res 32:1028-44
Zhu, Yu; Li, Jing; Kanvinde, Shrey et al. (2015) Self-immolative polycations as gene delivery vectors and prodrugs targeting polyamine metabolism in cancer. Mol Pharm 12:332-41
Vaz, A P; Ponnusamy, M P; Rachagani, S et al. (2014) Novel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic cancer stem cells. Br J Cancer 111:486-96
Joshi, Suhasini; Kumar, Sushil; Choudhury, Amit et al. (2014) Altered Mucins (MUC) trafficking in benign and malignant conditions. Oncotarget 5:7272-84
Souchek, J J; Baine, M J; Lin, C et al. (2014) Unbiased analysis of pancreatic cancer radiation resistance reveals cholesterol biosynthesis as a novel target for radiosensitisation. Br J Cancer 111:1139-49
Kaur, Sukhwinder; Sharma, Neil; Krishn, Shiv Ram et al. (2014) MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-*B signaling in pancreatic cancer. Clin Cancer Res 20:688-700
Liu, Xiang; Yi, Chunhui; Wen, Yunfei et al. (2014) Interactions between MUC1 and p120 catenin regulate dynamic features of cell adhesion, motility, and metastasis. Cancer Res 74:1609-20
Momi, Navneet; Kaur, Sukhwinder; Rachagani, Satyanarayana et al. (2014) Smoking and microRNA dysregulation: a cancerous combination. Trends Mol Med 20:36-47
Stark, Jaime L; Mehla, Kamiya; Chaika, Nina et al. (2014) Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer. Biochemistry 53:1360-72

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