The outcome of treating primary and metastatic brain tumors with anti-angiogenic therapy in which these agents were delivered in conjunction with chemotherapy and irradiation has been limited to minimal increase in the survival of patients. Paradoxically, in certain mouse tumor models, anti-angiogenic agents injected as single agents, presumably through the inducfion of hypoxia, have enhanced tumor invasiveness. These data have suggested that endothelial cells (ECs) regulate tumor growth not merely by passively delivering oxygen and nutrients. ECs also establish an instructive vascular niche that by production of paracrine growth factors, which we define as

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163167-02
Application #
8555354
Study Section
Special Emphasis Panel (ZCA1-SRLB-3 (O1))
Project Start
2011-09-21
Project End
2013-06-15
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
2
Fiscal Year
2012
Total Cost
$400,161
Indirect Cost
$128,663
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
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