RFA-CA-13-010 is a unique funding opportunity that challenges applicants to respond to some of the fundamental problems concerning HIV-associated malignancies in sub-Saharan Africa. It requires not only the performance of research in the short-term but also has a long-term view in its call for career development and research capacity building. This array of required activities must be accomplished via collaboration between a U.S. institution and a sub-Saharan African country, which might be separated by as much as 10,000 miles and a time differential of 11 hours. In response to this RFA, the """"""""Uganda-UCSF Consortium on Prevention and Early Detection of HIV-associated Cancer"""""""" recognizes the importance of each of the required elements and appreciates the complexity of the tasks at hand. In the realm of capacity building, the Uganda- UCSF Consortium will model its activities at the Infectious Diseases Institute (IDI) in Uganda after the NIH institutional K award programs that are successful breeding grounds for emerging scientists in the U.S. For the required research, it will conduct 3 sophisticated projects. To manage the complexity of the collection of required activities of the RFA, the Administrative/Coordinating Core of the Uganda-UCSF Consortium will:
Aim 1. Facilitate internal communication and coordination between consortium members and consortium activities.
Aim 2. Lead efforts in external interactions with local stakeholders, funders, and other NCI consortium members.
Aim 3. Provide financial oversight for the career development and research objectives of the consortium.
Aim 4. Monitor and evaluate progress of the consortium. At the end of the 5-year funding cycle, it is anticipated that the Administrative/Coordinating Core will have not only fulfilled the nominal requirements of the RFA but will have also maximized the use of our financial resources and guided the consortium towards its next set of capacity-building and research goals. In addition, it is expected that the Administrative/Coordinating Core will serve as another substrate for our emerging Ugandan principal investigators to use as a model as they build leadership skills in research.

Public Health Relevance

This project is bringing together scientists from both the University of California, San Francisco (UCSF) and Uganda to study cancer and HIV infection in sub-Saharan Africa. It requires scientists to not only perform research but also to build capacity in Uganda such that African researchers can begin to lead sophisticated research projects on their own. To keep the project organized and well managed financially, a central Administrative and Coordinating group will be formed with representatives from both the US and Africa.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-RPRB-O (M2))
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Dominguez, Geraldina
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University of California San Francisco
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Amerson, Erin; Woodruff, Carina Martin; Forrestel, Amy et al. (2016) Accuracy of Clinical Suspicion and Pathologic Diagnosis of Kaposi Sarcoma in East Africa. J Acquir Immune Defic Syndr 71:295-301
Nakalembe, Miriam; Mutyaba, Twaha; Mirembe, Florence (2016) Acceptability of study procedures (self-collected introital swabs, blood draws and stool sample collection) by students 10-16 years for an HPV vaccine effectiveness study: a pilot study. BMC Res Notes 9:170
Semeere, Aggrey; Wenger, Megan; Busakhala, Naftali et al. (2016) A prospective ascertainment of cancer incidence in sub-Saharan Africa: The case of Kaposi sarcoma. Cancer Med 5:914-28
Huchko, Megan J; Maloba, May; Nakalembe, Miriam et al. (2015) The time has come to make cervical cancer prevention an essential part of comprehensive sexual and reproductive health services for HIV-positive women in low-income countries. J Int AIDS Soc 18:20282
Freeman, Esther; Semeere, Aggrey; Wenger, Megan et al. (2015) Pitfalls of practicing cancer epidemiology in resource-limited settings: the case of survival and loss to follow-up after a diagnosis of Kaposi's sarcoma in five countries across sub-Saharan Africa. BMC Cancer 16:65
Tjiam, M Christian; Taylor, James P A; Morshidi, Mazmah A et al. (2015) Viremic HIV Controllers Exhibit High Plasmacytoid Dendritic Cell-Reactive Opsonophagocytic IgG Antibody Responses against HIV-1 p24 Associated with Greater Antibody Isotype Diversification. J Immunol 194:5320-8
Laker-Oketta, Miriam O; Wenger, Megan; Semeere, Aggrey et al. (2015) Task Shifting and Skin Punch for the Histologic Diagnosis of Kaposi's Sarcoma in Sub-Saharan Africa: A Public Health Solution to a Public Health Problem. Oncology 89:60-5
Forrestel, A K; Naujokas, A; Martin, J N et al. (2015) Bacillary angiomatosis masquerading as Kaposi's sarcoma in East Africa. J Int Assoc Provid AIDS Care 14:21-5
McKnight, Tracy R; Yoshihara, Hikari A I; Sitole, Lungile J et al. (2014) A combined chemometric and quantitative NMR analysis of HIV/AIDS serum discloses metabolic alterations associated with disease status. Mol Biosyst 10:2889-97