Abstract

SHARED RESOURCE CORE - IMAGING AND RADIOCHEMISTRY CORE (CORE B) Project Abstract/Summary The research proposed in the MC2TCN is focused on particle-driven, multi-modality translational developments of radiolabeled ultra-small fluorescent core-shell silica nanoparticles for oncologic diagnostic imaging and therapy. In support of this overarching theme, the Imaging and Radiochemistry Core will provide expertise and state-of-the-art instrumentation in positron emission tomography (PET), fluorescence imaging, and cyclotron production of radionuclides. The specific functions, then, of the Core are to provide for the research projects - both using small animal (rodents) and larger animal models (miniswine) - in vivo structural and functional imaging capabilities, related image display, analysis, and data management tools, cyclotron-produced positron- emitting radioisotopes (e.g., iodine-124 (124I) for synthesis of clinical-grade nanoparticle-based molecular tracers, and compartmental modeling-based kinetic analysis and radiation dosimetry software and expertise.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54CA199081-01
Application #
8961776
Study Section
Special Emphasis Panel (ZCA1-TCRB-Q (M1))
Project Start
2015-08-27
Project End
2020-07-31
Budget Start
2015-08-27
Budget End
2016-07-31
Support Year
1
Fiscal Year
2015
Total Cost
$215,347
Indirect Cost
$58,074

  Institution

Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Grüner, Florian; Blumendorf, Florian; Schmutzler, Oliver et al. (2018) Localising functionalised gold-nanoparticles in murine spinal cords by X-ray fluorescence imaging and background-reduction through spatial filtering for human-sized objects. Sci Rep 8:16561
Chen, Feng; Ma, Kai; Madajewski, Brian et al. (2018) Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer. Nat Commun 9:4141
Nath, Pooja; Mangal, Rahul; Kohle, Ferdinand et al. (2018) Dynamics of Nanoparticles in Entangled Polymer Solutions. Langmuir 34:241-249
Chen, Feng; Zhang, Xiuli; Ma, Kai et al. (2018) Melanocortin-1 Receptor-Targeting Ultrasmall Silica Nanoparticles for Dual-Modality Human Melanoma Imaging. ACS Appl Mater Interfaces 10:4379-4393
Ma, Kai; Gong, Yunye; Aubert, Tangi et al. (2018) Self-assembly of highly symmetrical, ultrasmall inorganic cages directed by surfactant micelles. Nature 558:577-580
He, Frank; Chiou, Aaron E; Loh, Hyun Chae et al. (2017) Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis. Proc Natl Acad Sci U S A 114:10542-10547
Chen, Feng; Ma, Kai; Benezra, Miriam et al. (2017) Cancer-Targeting Ultrasmall Silica Nanoparticles for Clinical Translation: Physicochemical Structure and Biological Property Correlations. Chem Mater 29:8766-8779
Chen, Feng; Ma, Kai; Zhang, Li et al. (2017) Target-or-Clear Zirconium-89 Labeled Silica Nanoparticles for Enhanced Cancer-Directed Uptake in Melanoma: A Comparison of Radiolabeling Strategies. Chem Mater 29:8269-8281
Yoo, B; Ma, K; Wiesner, U et al. (2017) Expanding Analytical Tools for Characterizing Ultrasmall Silica-based Nanoparticles. RSC Adv 7:16861-16865
Bradbury, Michelle S; Pauliah, Mohan; Zanzonico, Pat et al. (2016) Intraoperative mapping of sentinel lymph node metastases using a clinically translated ultrasmall silica nanoparticle. Wiley Interdiscip Rev Nanomed Nanobiotechnol 8:535-53

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