Abstract

Core 1 The Cell Microenvironment core will provide enabling technologies and develop new methods for controlling the cellular microenvironment and measuring its effect on cancer cell migration. The primary goals of the core will be to probe microenvironmental regulators of cell migration to inform mathematical models, probe cell migration within a physiologically relevant context, and develop highly parallelized platforms for high throughput studies. Technologies will include, but not be limited to, tools for controlling the mechanical environment, controlling cell and environment architecture, controlling cell organization within the microenvironment, controlling chemical gradients, controlling extracellular chemistry, measuring cell migration, and measuring cell force generation. In addition, tools will be developed for high-throughput cell migration measurement and high-throughput tissue isolation. The Cell Microenvironment core will support both Project 1 and Project 2 within this center as well as any applicable pilot projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA210190-03
Application #
9535258
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2018-08-01
Budget End
2019-07-31
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Marholz, Laura J; Zeringo, Nicholas A; Lou, Hua Jane et al. (2018) In Silico Design and in Vitro Characterization of Universal Tyrosine Kinase Peptide Substrates. Biochemistry 57:1847-1851
Estabridis, Horacio M; Jana, Aniket; Nain, Amrinder et al. (2018) Cell Migration in 1D and 2D Nanofiber Microenvironments. Ann Biomed Eng 46:392-403
Doak, Geneva R; Schwertfeger, Kathryn L; Wood, David K (2018) Distant Relations: Macrophage Functions in the Metastatic Niche. Trends Cancer 4:445-459
Tabdanov, Erdem D; Puram, Vikram V; Win, Zaw et al. (2018) Bimodal sensing of guidance cues in mechanically distinct microenvironments. Nat Commun 9:4891
Ray, Arja; Morford, Rachel K; Provenzano, Paolo P (2018) Cancer Stem Cell Migration in Three-Dimensional Aligned Collagen Matrices. Curr Protoc Stem Cell Biol 46:e57
Brett, Marie-Elena; Bomberger, Heather E; Doak, Geneva R et al. (2018) In vitro elucidation of the role of pericellular matrix in metastatic extravasation and invasion of breast carcinoma cells. Integr Biol (Camb) 10:242-252
Wu, Hao; de León, Marco Avila Ponce; Othmer, Hans G (2018) Getting in shape and swimming: the role of cortical forces and membrane heterogeneity in eukaryotic cells. J Math Biol 77:595-626
Shao, Qi; Liu, Feng; Chung, Connie et al. (2018) Physical and Chemical Enhancement of and Adaptive Resistance to Irreversible Electroporation of Pancreatic Cancer. Ann Biomed Eng 46:25-36
Elahi-Gedwillo, Kianna Y; Carlson, Marjorie; Zettervall, Jon et al. (2018) Antifibrotic therapy disrupts stromal barriers and modulates the immune landscape in pancreatic ductal adenocarcinoma. Cancer Res :
Tabdanov, Erdem D; Puram, Vikram; Zhovmer, Alexander et al. (2018) Microtubule-Actomyosin Mechanical Cooperation during Contact Guidance Sensing. Cell Rep 25:328-338.e5

Showing the most recent 10 out of 20 publications