The Biostatistics Core provides comprehensive data processing and analysis services for the Specialized Research Center (P50), on "Evaluating New Nicotine Standards for Cigarettes". These include form design, study design, and statistical analysis. These services will be provided to investigators and leaders of the four main projects in the proposed specialized research center, as well as to Cores A and B if necessary. The Core director. Dr. Chap Le, and Core co-director. Dr. Xianghua Luo, who will manage and direct the Core, have extensive experience in the areas of biostatistics and tobacco research and also manage many similar large projects in the Biostatistics and Bioinformatics Core of the University of Minnesota Comprehensive Cancer Center. Statistical expertise in the Core is particularly noteworthy in regard to the projects proposed for this P50 which include several randomized trials. It is believed that this group will be an important and essential asset to investigators of this specialized research center.

Public Health Relevance

The goal of the Biostatistics Core, Core C, is to support and promote high quality, team-oriented, and transdisciplinary research on tobacco evaluation as proposed in this grant application. The Core will be responsible for assisting the Project Leaders in study design, data collection and processing, quality control, data storage and retrieval, and statistical data analysis.

Agency
National Institute of Health (NIH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54DA031659-04
Application #
8710135
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
Hatsukami, Dorothy K; Donny, Eric C; Koopmeiners, Joseph S et al. (2015) Compensatory smoking from gradual and immediate reduction in cigarette nicotine content. Cancer Epidemiol Biomarkers Prev 24:472-6
Vogel, Rachel Isaksson; Hertsgaard, Louise A; Dermody, Sarah S et al. (2014) Sex differences in response to reduced nicotine content cigarettes. Addict Behav 39:1197-204
Tidey, Jennifer W; Colby, Suzanne M; Xavier, Emily M H (2014) Effects of smoking abstinence on cigarette craving, nicotine withdrawal, and nicotine reinforcement in smokers with and without schizophrenia. Nicotine Tob Res 16:326-34
Smith, Tracy T; Schassburger, Rachel L; Buffalari, Deanne M et al. (2014) Low-dose nicotine self-administration is reduced in adult male rats naïve to high doses of nicotine: implications for nicotine product standards. Exp Clin Psychopharmacol 22:453-9
Dermody, Sarah S; Donny, Eric C (2014) The predicted impact of reducing the nicotine content in cigarettes on alcohol use. Nicotine Tob Res 16:1033-44
Donny, Eric C; Hatsukami, Dorothy K; Benowitz, Neal L et al. (2014) Reduced nicotine product standards for combustible tobacco: building an empirical basis for effective regulation. Prev Med 68:17-22
Hatsukami, Dorothy K; Heishman, Stephen J; Vogel, Rachel Isaksson et al. (2013) Dose-response effects of spectrum research cigarettes. Nicotine Tob Res 15:1113-21
Hatsukami, Dorothy K; Benowitz, Neal L; Donny, Eric et al. (2013) Nicotine reduction: strategic research plan. Nicotine Tob Res 15:1003-13
Hatsukami, Dorothy K; Hertsgaard, Louise A; Vogel, Rachel I et al. (2013) Reduced nicotine content cigarettes and nicotine patch. Cancer Epidemiol Biomarkers Prev 22:1015-24
Tidey, Jennifer W; Rohsenow, Damaris J; Kaplan, Gary B et al. (2013) Separate and combined effects of very low nicotine cigarettes and nicotine replacement in smokers with schizophrenia and controls. Nicotine Tob Res 15:121-9

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