Results from tissue culture and animal models provide important information, but must be validated in human tissue to be considered clinically relevant. Thus, the success of this O'Brien Center will depend upon the availability of high quality, appropriately selected human tissue specimens. The Tissue Resources and Morphology Core (TRMC) will supply such material. The TRMC will be based on the Health Sciences Tissue Bank, a core facility that has been accruing prostate tissue from BPH patients for over 15 years. The Director of the Health Sciences Tissue Bank, Dr. Rajiv Dhir, a board certified pathologist with training in genitourinary pathology, will serve as the TRMC Director. Dr. Dhir will assure the proper use and analysis of BPH specimens in the proposed projects. The TRMC will provide an array of services: (1) Procurement of normal and diseased prostates and bladders; (2) Banking of specimens; (3) Data collection to annotate samples, specimen data entry, and inventory management; (4) Morphology support for appropriate case selection for the proposed studies; (5) Histology support and immunohistochemistry. Tissue microarray development will be done for high throughput assessment, if needed. (6) Support and assistance for Institutional Review Board issues.

Public Health Relevance

The success of this O'Brien Center will depend upon the availability of high quality, appropriately selected human tissue specimens. The Tissue Resources and Morphology Core (TRMC) (Core B) will supply such material.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54DK112079-02
Application #
9357576
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2017-08-01
Budget End
2018-07-31
Support Year
2
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Tyagi, Pradeep; Motley, Saundra S; Koyama, Tatsuki et al. (2018) Molecular correlates in urine for the obesity and prostatic inflammation of BPH/LUTS patients. Prostate 78:17-24
Li, Feng; Pascal, Laura E; Zhou, Jianhua et al. (2018) BCL-2 and BCL-XL expression are down-regulated in benign prostate hyperplasia nodules and not affected by finasteride and/or celecoxib. Am J Clin Exp Urol 6:1-10
Mizoguchi, Shinsuke; Mori, Kenichi; Wang, Zhou et al. (2017) Effects of Estrogen Receptor ? Stimulation in a Rat Model of Non-Bacterial Prostatic Inflammation. Prostate 77:803-811