The long-term goals of our center include addressing the epidemics of STDs and HIV in the U.S. and in resource-poor settings by development and better use of Point-of-Care (POC) tests, so as to address health inequity and improve the sexual health of individuals Our specific aims are 1) Provide a Center administrative structure to ensure that the large, complex Center achieves its goals in a timely manner.2) Conduct integrated clinical needs assessments and health impact assessments from clinicians, end-users, and other appropriate stakeholders, with the anticipation to advance and inform the field of POC testing design, development, and utilization by disseminating this information to the technology development community.3) Collaborate with physical and biochemical scientists, computational scientists, and systems engineers on a) exploratory technology for prototype development projects and b) for testing of more mature POCTs to insure a logical progression of assays along a pipeline from the concept stage to the clinical testing stage. 4) To test mature POC assays in clinical situations and in resource poor countries in order to enhance use of POC tests in settings such as emergency departments, home testing and to advance clinical acceptance and use of such tests and thus improve health especially for those experiencing health disparities and inequities.5) Provide training to technology developers across various career levels on clinical and process issues as well as needs related to the development of POC devices in an iterative fashion, as well as provide training for scientists in resource poor settins and education of relevant stakeholders on the development and potential impact of POC technologies. These goals and aims will be accomplished by an effective administrative component, ascertaining needs of users of POC, training of scientists, funding scientists and engineers for development of prototype and mature POC technologies, and pilot testing and implementation of POC tests in diverse clinical settings, which will lead to the commercialization and use of POC tests for diagnosing STDs in order to improve the sexual health of individuals in the United States and the rest of the world.

Public Health Relevance

of this project to public health is that by use of Point-of Care tests to rapidly and accurately diagnose sexually transmitted diseases (STDs), the sexual health of individuals in both the U.S. and in resource poor settings through the world will be improved. Rapid diagnosis and prompt treatment will improve sexual health in the world and prevent the spread of these infectious diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
2U54EB007958-06
Application #
8340516
Study Section
Special Emphasis Panel (ZEB1-OSR-D (M2))
Program Officer
Korte, Brenda
Project Start
2007-09-30
Project End
2017-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
6
Fiscal Year
2012
Total Cost
$1,654,462
Indirect Cost
$482,401
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Paterson, Andrew S; Raja, Balakrishnan; Mandadi, Vinay et al. (2017) A low-cost smartphone-based platform for highly sensitive point-of-care testing with persistent luminescent phosphors. Lab Chip 17:1051-1059
Butzler, Matthew A; Reed, Jennifer L; McFall, Sally M (2017) A simple and rapid DNA extraction method for Chlamydia trachomatis detection from urogenital swabs. Diagn Microbiol Infect Dis 89:182-184
Gaydos, Charlotte A; Beqaj, Sajo; Schwebke, Jane R et al. (2017) Clinical Validation of a Test for the Diagnosis of Vaginitis. Obstet Gynecol 130:181-189
Lewis, Mitra K; Hsieh, Yu-Hsiang; Gaydos, Charlotte A et al. (2017) Informed consent for opt-in HIV testing via tablet kiosk: an assessment of patient comprehension and acceptability. Int J STD AIDS 28:1292-1298
Gaydos, Charlotte A; Klausner, Jeffrey D; Pai, Nitika Pant et al. (2017) Rapid and point-of-care tests for the diagnosis of Trichomonas vaginalis in women and men. Sex Transm Infect 93:S31-S35
Gaydos, C A; Schwebke, J; Dombrowski, J et al. (2017) Clinical performance of the Solana® Point-of-Care Trichomonas Assay from clinician-collected vaginal swabs and urine specimens from symptomatic and asymptomatic women. Expert Rev Mol Diagn 17:303-306
Postenrieder, Nikki R; Reed, Jennifer L; Hesse, Elizabeth et al. (2016) Rapid Antigen Testing for Trichomoniasis in an Emergency Department. Pediatrics 137:
Orlando, Megan S; Rothman, Richard E; Woodfield, Alonzo et al. (2016) Public Health Information Delivery in the Emergency Department: Analysis of a Kiosk-Based Program. J Emerg Med 50:223-7
Gaydos, Charlotte A; Jett-Goheen, Mary; Barnes, Mathilda et al. (2016) Use of a risk quiz to predict infection for sexually transmitted infections: a retrospective analysis of acceptability and positivity. Sex Transm Infect 92:44-8
Gaydos, Charlotte A; Jett-Goheen, Mary; Barnes, Mathilda et al. (2016) Self-testing for Trichomonas vaginalis at home using a point-of-care test by women who request kits via the Internet. Sex Health :

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