We will create a database of optical properties from various human effusions samples to develop diagnostic criteria. Middle ear fluid specimens will be provided by our clinical colleagues at the Massachusetts Eye and Ear Infirmary (MEEI). These specimens and fluids are routinely aspirated and discarded during bilateral myringotomy with tube insertion. Research specimens used in Aim 2 will be obtained from these discarded human specimens. All specimens will be de-identified and are exempt from human subjects research study, according to DHHS human subject regulation exemption 4. Prior to the start of this study, an exempt human subjects protocol will be submitted for approval by the Partners IRB. Research that meets the criteria for Exemption 4 is not considered "clinical research" as defined by NIH. Therefore, the NIH policies for inclusion of women, minorities and children in clinical research, and targeted/planned enrollment tables, do not apply to research projects covered by Exemption 4. Sections regarding the Protection of Human Subjects, Women &Minorities, Planned Enrollment Table, and Inclusion of Children are not included because the proposed research with human materials is not considered clinical research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54EB015408-01
Application #
8467246
Study Section
Special Emphasis Panel (ZEB1-OSR-D (M2))
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
1
Fiscal Year
2012
Total Cost
$177,315
Indirect Cost
$75,556
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Hassan, Umer; Watkins, Nicholas N; Reddy Jr, Bobby et al. (2016) Microfluidic differential immunocapture biochip for specific leukocyte counting. Nat Protoc 11:714-26
El Assal, Rami; Gurkan, Umut A; Chen, Pu et al. (2016) 3-D Microwell Array System for Culturing Virus Infected Tumor Cells. Sci Rep 6:39144
Asghar, Waseem; Yuksekkaya, Mehmet; Shafiee, Hadi et al. (2016) Engineering long shelf life multi-layer biologically active surfaces on microfluidic devices for point of care applications. Sci Rep 6:21163
Lifson, Mark A; Ozen, Mehmet Ozgun; Inci, Fatih et al. (2016) Advances in biosensing strategies for HIV-1 detection, diagnosis, and therapeutic monitoring. Adv Drug Deliv Rev 103:90-104
Wang, ShuQi; Chinnasamy, Thiruppathiraja; Lifson, Mark A et al. (2016) Flexible Substrate-Based Devices for Point-of-Care Diagnostics. Trends Biotechnol 34:909-921
Wang, ShuQi; Lifson, Mark A; Inci, Fatih et al. (2016) Advances in addressing technical challenges of point-of-care diagnostics in resource-limited settings. Expert Rev Mol Diagn 16:449-59
Rodriguez, Natalia M; Wong, Winnie S; Liu, Lena et al. (2016) A fully integrated paperfluidic molecular diagnostic chip for the extraction, amplification, and detection of nucleic acids from clinical samples. Lab Chip 16:753-63
Shafiee, Hadi; Wang, ShuQi; Inci, Fatih et al. (2015) Emerging technologies for point-of-care management of HIV infection. Annu Rev Med 66:387-405
Inci, Fatih; Filippini, Chiara; Baday, Murat et al. (2015) Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics. Proc Natl Acad Sci U S A 112:E4354-63
Yildiz, U Hakan; Inci, Fatih; Wang, ShuQi et al. (2015) Recent advances in micro/nanotechnologies for global control of hepatitis B infection. Biotechnol Adv 33:178-90

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