Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54GM094610-05
Application #
8715822
Study Section
Special Emphasis Panel (ZGM1-CBB-3)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
$119,475
Indirect Cost
$13,483
Name
California Institute of Technology
Department
Type
DUNS #
009584210
City
Pasadena
State
CA
Country
United States
Zip Code
91125
Vastermark, Ake; Saier Jr, Milton H (2014) Evolutionary relationship between 5+5 and 7+7 inverted repeat folds within the amino acid-polyamine-organocation superfamily. Proteins 82:336-46
Saier Jr, Milton H; Reddy, Vamsee S; Tamang, Dorjee G et al. (2014) The transporter classification database. Nucleic Acids Res 42:D251-8
Swartz, Douglas J; Mok, Leo; Botta, Sri K et al. (2014) Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance. Biosci Rep 34:
Västermark, Ake; Lunt, Bryan; Saier, Milton (2014) Major facilitator superfamily porters, LacY, FucP and XylE of Escherichia coli appear to have evolved positionally dissimilar catalytic residues without rearrangement of 3-TMS repeat units. J Mol Microbiol Biotechnol 24:82-90
Reddy, Abhinay; Cho, Jaehoon; Ling, Sam et al. (2014) Reliability of nine programs of topological predictions and their application to integral membrane channel and carrier proteins. J Mol Microbiol Biotechnol 24:161-90
Saier Jr, Milton H (2013) Microcompartments and protein machines in prokaryotes. J Mol Microbiol Biotechnol 23:243-69
Swartz, Douglas J; Weber, Joachim; Urbatsch, Ina L (2013) P-glycoprotein is fully active after multiple tryptophan substitutions. Biochim Biophys Acta 1828:1159-68
Zheng, Wei Hao; Vastermark, Ake; Shlykov, Maksim A et al. (2013) Evolutionary relationships of ATP-Binding Cassette (ABC) uptake porters. BMC Microbiol 13:98
Pieper, Ursula; Schlessinger, Avner; Kloppmann, Edda et al. (2013) Coordinating the impact of structural genomics on the human *-helical transmembrane proteome. Nat Struct Mol Biol 20:135-8
Bai, Jiangping; Swartz, Douglas J; Protasevich, Irina I et al. (2011) A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris. PLoS One 6:e22577