Overview. The mission of the OSCTR is to serve as a catalyst to facilitate clinical research into relevant health improvements for underserved and underrepresented populations living in rural areas, to improve patient outcomes, and to provide these resources to investigators and patients from other IDeA states. Thus, the OSCTR and its collaborating partners have identified the following goals: (1) Enhance the development of high-caliber OSCTR clinical translational scientists who focus on health issues of concern to our populations through training, mentoring and pilot grant opportunities, (2) Establish the OSCTR Research Navigator Service to facilitate access to research infrastructure, (3) Develop and share infrastructure to support Clinical and Translational Research (CTR) throughout Oklahoma, Kansas, Arkansas, South Carolina, Alaska and future collaborating IDeA states, (4) Promote research on diseases with high prevalence among American Indians and Alaskan Natives, (5) Utilize and build registries and repositories to better understand disease mechanisms and to help launch junior OSCTR clinical investigative careers, (6) Engage communities through practice based research networks to identify and conduct research of highest interest to Oklahoma and other IDeA communities, (7) Mentor early stage OSCTR clinical investigators to research independence. Preliminary assessment reveals the complexity of the project, as it involves multiple institutions combining strengths in basic and applied research, clinical service, and practice research to enhance clinical care outcomes, particularly in addressing the needs of special populations. The proposed evaluation will work with the distinctiveness of this application to address the needs of stakeholders (broadly defined, e.g., OSCTR investigators, trainees, staff, community members) in the realization of the OSCTR goals. The Evaluation Core will rigorously evaluate the overall operational functions of the OSCTR and Key Component Activities (KCAs) and outcomes. In this proposal, we set out a broad plan to evaluate implementation of short-term and long-term goals using a goals-based evaluation framework and logic model (Figure 1). We will do this for the OSCTR as a whole, and will facilitate this level of evaluation within each of the KCAs. Note that KCA leaders have proposed specific milestones and tracking measures for the success of their operations in the activity and timeline tables later in this section. These primarily focus on process measures and represent one level of OSCTR evaluation

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54GM104938-01A1
Application #
8608749
Study Section
Special Emphasis Panel (ZGM1-TWD-C (CC))
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$151,639
Indirect Cost
$49,180
Name
University of Oklahoma Health Sciences Center
Department
Type
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Pelikan, Richard C; Kelly, Jennifer A; Fu, Yao et al. (2018) Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks. Nat Commun 9:2905
Patel, Zubin; Lu, Xiaoming; Miller, Daniel et al. (2018) A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Hum Mol Genet :
Kheir, Joseph M; Guthridge, Carla J; Johnston, Jonathon R et al. (2018) Unique clinical characteristics, autoantibodies and medication use in Native American patients with systemic lupus erythematosus. Lupus Sci Med 5:e000247
Young, K A; Munroe, M E; Harley, J B et al. (2018) Less than 7 hours of sleep per night is associated with transitioning to systemic lupus erythematosus. Lupus 27:1524-1531
Jog, Neelakshi R; Chakravarty, Eliza F; Guthridge, Joel M et al. (2018) Epstein Barr Virus Interleukin 10 Suppresses Anti-inflammatory Phenotype in Human Monocytes. Front Immunol 9:2198
Ojeda, Ann S; Widener, Jeffrey; Aston, Christopher E et al. (2018) ESRD and ESRD-DM associated with lignite-containing aquifers in the U.S. Gulf Coast region of Arkansas, Louisiana, and Texas. Int J Hyg Environ Health 221:958-966
Carabin, Hélène; Millogo, Athanase; Ngowi, Helena A et al. (2018) Effectiveness of a community-based educational programme in reducing the cumulative incidence and prevalence of human Taenia solium cysticercosis in Burkina Faso in 2011-14 (EFECAB): a cluster-randomised controlled trial. Lancet Glob Health 6:e411-e425
Comiford, Ashley; Garroutte, Eva; Barbosa-Leiker, Celestina et al. (2018) Prevalence and Indicators of Household Smoking Bans Among American Indians. J Community Health 43:746-755
Chen, Sixia; Haziza, David (2018) Jackknife empirical likelihood method for multiply robust estimation with missing data. Comput Stat Data Anal 127:258-268
Goodman, Jean R; Peck, Jennifer D; Landmann, Alessandra et al. (2018) An evaluation of nutritional and vasoactive stimulants as risk factors for gastroschisis: a pilot study. J Matern Fetal Neonatal Med :1-8

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