Clinical and translational research (CTR) requires well characterized patient cohorts partnered with appropriately collected and stored biospecimens. However, the time, energy and resources required to amass such resources are oftentimes scarce or just not available, especially to junior investigators or to investigators new to clinical and translational research. Investigators at the University of Oklahoma Health Sciences Center (OUHSC) and Oklahoma Medical Research Foundation (OMRF) have established and maintained patient cohorts that encompass a wide range of diseases. Research involving these cohorts has supported the career development of junior investigators, both local and elsewhere. Established investigators also use these resources. Along with institutional support, a variety of funding mechanisms support these research cohorts. The most mature of these clinical research resources is the Lupus Family Registry and Repository (LFRR), which received support through an NIH contract for more than 15 years. The LFRR identifies families with systemic lupus erythematosus (SLE), and collects clinical information as well as biological samples. At present approximately 3000 SLE patients, 8000 family members and 2000 healthy controls are included with over 1000 data points stored in a searchable, HlPAA-compliant database. De-identified samples and/or information have been sent to 101 investigators around the world, and over 150 manuscripts have been published using these data. However, this critical resource has not been used to explore pathogenic mechanisms in common comorbidities, such as hypertension, diabetes and atherosclerosis. Another longitudinal cohort was established some 20 years ago. It maintains information on patients with thrombotic thrombocytopenic purpura (TTP) and is one of the largest in the world. Similar to the I.FRR, a wealth of clinical information is available within this database, but it is not completely satisfactory for clinical research. Because of limited funding, this cohort does not contain associated samples. Other cohorts at various stages of development in OSCTR institutions include pregnant American Indians, diabetes mellitus, rheumatic diseases, pancreatic cancer and multiple sclerosis.

Agency
National Institute of Health (NIH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54GM104938-02
Application #
8727635
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117
Munroe, Melissa E; Young, Kendra A; Kamen, Diane L et al. (2016) Soluble Mediators and Clinical Features Discern Risk of Transitioning to Classified Disease in Relatives of Systemic Lupus Erythematosus Patients. Arthritis Rheumatol :
Rostaminia, Ghazaleh; Peck, Jennifer D; Quiroz, Lieschen H et al. (2016) Characteristics associated with pelvic organ prolapse in women with significant levator ani muscle deficiency. Int Urogynecol J 27:261-7
Rabadi, Meheroz H; Aston, Christopher E (2016) Compare serum creatinine versus Renal (99m)Tc-DTPA scan determined glomerular filtration rates in veterans with traumatic spinal cord injury and meurogenic bladder. J Spinal Cord Med 39:638-644
Sandhya, Pulukool; Kurien, Biji Theyilamannil; Danda, Debashish et al. (2016) Update on Pathogenesis of Sjögren's syndrome. Curr Rheumatol Rev :
Hannafon, Bethany N; Trigoso, Yvonne D; Calloway, Cameron L et al. (2016) Plasma exosome microRNAs are indicative of breast cancer. Breast Cancer Res 18:90
Young, Kendra A; Munroe, Melissa E; Guthridge, Joel M et al. (2016) Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus. Ann Rheum Dis :
Wolska, Nina; Rybakowska, Paulina; Rasmussen, Astrid et al. (2016) Brief Report: Patients With Primary Sjögren's Syndrome Who Are Positive for Autoantibodies to Tripartite Motif-Containing Protein 38 Show Greater Disease Severity. Arthritis Rheumatol 68:724-9
Heu, May Kou; Welborn, Toney; Nagykaldi, Zsolt (2016) Clinical Question: In adult patients on warfarin, does-home-self-testing of prothrombin time and/or international normalized ratio provide the same outcomes compared to testing by a home health nurse or in a clinical setting? J Okla State Med Assoc 109:99-100
Bonney, Phillip A; Maurer, Adrian J; Cheema, Ahmed A et al. (2016) Clinical significance of changes in pB-C2 distance in patients with Chiari Type I malformations following posterior fossa decompression: a single-institution experience. J Neurosurg Pediatr 17:336-42
Lu, Rufei; Munroe, Melissa E; Guthridge, Joel M et al. (2016) Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies. J Autoimmun 74:182-193

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